Device and method for automated separation of a sample of whole blood into aliquots

Patent · Sun Jan 01 00:00:00 EST 1989

OSTI ID:867032

Burtis, Carl A ^[1]; Johnson, Wayne F ^[2]

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1. Oak Ridge, TN
2. Loudon, TN

A device and a method for automated processing and separation of an unmeasured sample of whole blood into multiple aliquots of plasma. Capillaries are radially oriented on a rotor, with the rotor defining a sample chamber, transfer channels, overflow chamber, overflow channel, vent channel, cell chambers, and processing chambers. A sample of whole blood is placed in the sample chamber, and when the rotor is rotated, the blood moves outward through the transfer channels to the processing chambers where the blood is centrifugally separated into a solid cellular component and a liquid plasma component. When the rotor speed is decreased, the plasma component backfills the capillaries resulting in uniform aliquots of plasma which may be used for subsequent analytical procedures.

• Research Organization: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
• Assignee: Martin Marietta Energy Systems, Inc. (Oak Ridge, TN)
• Patent Number(s): US 4847205
• OSTI ID: 867032
• Country of Publication: United States
• Language: English

Related Subjects

device
method
automated
separation
sample
blood
aliquots
processing
unmeasured
multiple
plasma
capillaries
radially
oriented
rotor
defining
chamber
transfer
channels
overflow
channel
cell
chambers
placed
rotated
moves
outward
centrifugally
separated
solid
cellular
component
liquid
speed
decreased
backfills
resulting
uniform
subsequent
analytical
procedures
sample chamber
processing chamber
flow channel
flow chamber
automated process
cell chamber
rotor speed
cellular component
automated processing
automated separation
/436/422/494/