Method and apparatus for fringe-scanning chromosome analysis

Patent · Wed Jan 01 00:00:00 EST 1986

OSTI ID:865886

Norgren, Richard M ^[1]; Gray, Joe W ^[2]; Hirschfeld, Tomas B ^[2]

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1. Palo Alto, CA
2. Livermore, CA

Apparatus and method are provided for analyzing sub-micron-sized features of microscopic particles. Two central features of the invention are (1) constraining microscopic particles to flow with substantially constant orientation through a predetermined interference fringe pattern, and (2) estimating particle structure by analyzing its fringe profile. The invention allows nearly an order of magnitude higher resolution of chromosome structure than possible with currently available flow system techniques. The invention allows rapid and accurate flow karyotyping of chromosomes.

• Research Organization: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
• DOE Contract Number: W-7405-ENG-48
• Assignee: United States of America as represented by United States (Washington, DC)
• Patent Number(s): US 4596036
• OSTI ID: 865886
• Country of Publication: United States
• Language: English

Related Subjects

method
apparatus
fringe-scanning
chromosome
analysis
provided
analyzing
sub-micron-sized
features
microscopic
particles
central
constraining
flow
substantially
constant
orientation
predetermined
interference
fringe
pattern
estimating
particle
structure
profile
allows
nearly
magnitude
resolution
currently
available
techniques
rapid
accurate
karyotyping
chromosomes
microscopic particles
currently available
substantially constant
fringe pattern
interference fringe
analysis apparatus
/382/356/377/