Mutation assays involving blood cells that metabolize toxic substances

Patent · Tue Jan 01 00:00:00 EST 1985

OSTI ID:865535

Crespi, Charles L ^[1]; Thilly, William G ^[2]

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1. Downers Grove, IL
2. Winchester, MA

A line of human blood cells which have high levels of oxidative activity (such as oxygenase, oxidase, peroxidase, and hydroxylase activity) is disclosed. Such cells grow in suspension culture, and are useful to determine the mutagenicity of xenobiotic substances that are metabolized into toxic or mutagenic substances. Mutation assays using these cells, and other cells with similar characteristics, are also disclosed.

• Research Organization: Sandia National Laboratories (SNL), Albuquerque, NM, and Livermore, CA (United States)
• DOE Contract Number: AC04-76
• Assignee: Massachusetts Institute of Technology (Cambridge, MA)
• Patent Number(s): US 4532204
• OSTI ID: 865535
• Country of Publication: United States
• Language: English

Related Subjects

mutation
assays
involving
blood
cells
metabolize
toxic
substances
line
human
levels
oxidative
activity
oxygenase
oxidase
peroxidase
hydroxylase
disclosed
grow
suspension
culture
useful
determine
mutagenicity
xenobiotic
metabolized
mutagenic
similar
characteristics
blood cells
blood cell
mutation assays
human blood
metabolize toxic
oxidative activity
suspension culture
toxic substances
hydroxylase activity
cells grow
assays involving
involving blood
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