Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha
Abstract
Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORa up-regulates human APOA5 but has no effect on mouse apoa5 promoter. These data suggest an additional important physiological role for RORa in the regulation of genes involved in plasma triglyceride homeostasis in human and probably in the development of atherosclerosis
- Authors:
- Publication Date:
- Research Org.:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE. Office of Management Budget and Evaluation; National Institutes of Health Contract RHL071954A; Leducq Foundation (US)
- OSTI Identifier:
- 841115
- Report Number(s):
- LBNL-57328
R&D Project: GHRUB4; TRN: US0502354
- Resource Type:
- Journal Article
- Journal Name:
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Additional Journal Information:
- Journal Volume: 25; Other Information: Submitted to Arteriosclerosis, Thrombosis, and Vascular Biology: Volume 25; Journal Publication Date: 06/2005; PBD: 1 Oct 2004
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; APOLIPOPROTEINS; ARTERIOSCLEROSIS; GENES; HOMEOSTASIS; PLASMA; REGULATIONS; TRIGLYCERIDES; APOLIPOPROTEIN A5 NUCLEAR RECEPTOR RORA TRIGLYCERIDE HOMEOSTASIS TRANSCRIPTIONAL REGULATION
Citation Formats
Genoux, Annelise, Dehondt, Helene, Helleboid-Chapman, Audrey, Duhem, Christian, Hum, Dean W, Martin, Genevieve, Pennacchio, Len, Staels, Bart, Fruchart-Najib, Jamila, and Fruchart, Jean-Charles. Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha. United States: N. p., 2004.
Web.
Genoux, Annelise, Dehondt, Helene, Helleboid-Chapman, Audrey, Duhem, Christian, Hum, Dean W, Martin, Genevieve, Pennacchio, Len, Staels, Bart, Fruchart-Najib, Jamila, & Fruchart, Jean-Charles. Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha. United States.
Genoux, Annelise, Dehondt, Helene, Helleboid-Chapman, Audrey, Duhem, Christian, Hum, Dean W, Martin, Genevieve, Pennacchio, Len, Staels, Bart, Fruchart-Najib, Jamila, and Fruchart, Jean-Charles. 2004.
"Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha". United States. https://www.osti.gov/servlets/purl/841115.
@article{osti_841115,
title = {Transcriptional Regulation of Apolipoprotein A5 Gene Expression by the Nuclear Receptor ROR alpha},
author = {Genoux, Annelise and Dehondt, Helene and Helleboid-Chapman, Audrey and Duhem, Christian and Hum, Dean W and Martin, Genevieve and Pennacchio, Len and Staels, Bart and Fruchart-Najib, Jamila and Fruchart, Jean-Charles},
abstractNote = {Apolipoprotein A5 has recently been identified as a crucial determinant of plasma triglyceride levels. Our results showed that RORa up-regulates human APOA5 but has no effect on mouse apoa5 promoter. These data suggest an additional important physiological role for RORa in the regulation of genes involved in plasma triglyceride homeostasis in human and probably in the development of atherosclerosis},
doi = {},
url = {https://www.osti.gov/biblio/841115},
journal = {Arteriosclerosis, Thrombosis, and Vascular Biology},
number = ,
volume = 25,
place = {United States},
year = {Fri Oct 01 00:00:00 EDT 2004},
month = {Fri Oct 01 00:00:00 EDT 2004}
}
Other availability
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.