Human Genetic Marker for Resistance to Radiations and Chemicals

Lieberman, Howard B

doi:10.2172/827386

Title: Human Genetic Marker for Resistance to Radiations and Chemicals

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Abstract

The major goal of the research project is to define the role of HRAD9 in the response of cells to radiation or chemical exposure, and to establish this gene as a genetic marker to predict predisposition to the deleterious health effects that may result after exposure to these agents. HRAD9 is a human homologue of fission yeast S. pombe rad9, a gene known to promote radioresistance and chemoresistance, and to regulate cell cycle progression after DNA is damaged or DNA replication is incomplete -i.e., it mediates cell cycle checkpoint control. Therefore, HRAD9 likely plays an important role in humans to determine the biological consequences of DNA damage.

Authors:: Lieberman, Howard B

Publication Date:: Tue Jun 01 00:00:00 EDT 1999

Research Org.:: Columbia University, New York, New York (US)

Sponsoring Org.:: USDOE Office of Environmental Management (EM) (US)

OSTI Identifier:: 827386

Report Number(s):: EMSP-55100-1999
R&D Project: EMSP 55100; TRN: US200425%%633

DOE Contract Number:: FG07-96ER62309

Resource Type:: Technical Report

Resource Relation:: Other Information: PBD: 1 Jun 1999

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 54 ENVIRONMENTAL SCIENCES; 63 RADIATION, THERMAL, AND OTHER ENVIRONMENTAL POLLUTANT EFFECTS ON LIVING ORGANISMS AND BIOLOGICAL MATERIALS; CELL CYCLE; DNA; DNA DAMAGES; DNA REPLICATION; FISSION; GENES; GENETICS; RADIATIONS; RADIOSENSITIVITY; YEASTS

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                    Lieberman, Howard B. Human Genetic Marker for Resistance to Radiations and Chemicals.  United States: N. p., 1999. 
        Web.  doi:10.2172/827386.

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                    Lieberman, Howard B. Human Genetic Marker for Resistance to Radiations and Chemicals.  United States.  https://doi.org/10.2172/827386

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                    Lieberman, Howard B. 1999.  
        "Human Genetic Marker for Resistance to Radiations and Chemicals".  United States.  https://doi.org/10.2172/827386.  https://www.osti.gov/servlets/purl/827386.

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@article{osti_827386,

  title        = {Human Genetic Marker for Resistance to Radiations and Chemicals},

  author       = {Lieberman, Howard B},

  abstractNote = {The major goal of the research project is to define the role of HRAD9 in the response of cells to radiation or chemical exposure, and to establish this gene as a genetic marker to predict predisposition to the deleterious health effects that may result after exposure to these agents. HRAD9 is a human homologue of fission yeast S. pombe rad9, a gene known to promote radioresistance and chemoresistance, and to regulate cell cycle progression after DNA is damaged or DNA replication is incomplete -i.e., it mediates cell cycle checkpoint control. Therefore, HRAD9 likely plays an important role in humans to determine the biological consequences of DNA damage.},

  doi          = {10.2172/827386},

  url          = {https://www.osti.gov/biblio/827386},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jun 01 00:00:00 EDT 1999},

  month        = {Tue Jun 01 00:00:00 EDT 1999}

}

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