Theoretical evaluation of the detectability of random lesions in bayesian emission reconstruction
Detecting cancerous lesion is an important task in positron emission tomography (PET). Bayesian methods based on the maximum a posteriori principle (also called penalized maximum likelihood methods) have been developed to deal with the low signal to noise ratio in the emission data. Similar to the filter cut-off frequency in the filtered backprojection method, the prior parameters in Bayesian reconstruction control the resolution and noise trade-off and hence affect detectability of lesions in reconstructed images. Bayesian reconstructions are difficult to analyze because the resolution and noise properties are nonlinear and object-dependent. Most research has been based on Monte Carlo simulations, which are very time consuming. Building on the recent progress on the theoretical analysis of image properties of statistical reconstructions and the development of numerical observers, here we develop a theoretical approach for fast computation of lesion detectability in Bayesian reconstruction. The results can be used to choose the optimum hyperparameter for the maximum lesion detectability. New in this work is the use of theoretical expressions that explicitly model the statistical variation of the lesion and background without assuming that the object variation is (locally) stationary. The theoretical results are validated using Monte Carlo simulations. The comparisons show good agreement between the theoretical predications and the Monte Carlo results.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- USDOE Director, Office of Science, Office of Biological and Environmental Research, Medical Sciences Division; National Institute of Health Grant R01 EB00363, R01 EB00194 (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 815506
- Report Number(s):
- LBNL-52681; R&D Project: 80ZL01, 865A1A; TRN: US0304637
- Resource Relation:
- Conference: International Conference on Information Processing in Medical Imaging, Ambleside (GB), 07/20/2003--07/25/2003; Other Information: PBD: 1 May 2003
- Country of Publication:
- United States
- Language:
- English
Similar Records
Effective noise-suppressed and artifact-reduced reconstruction of SPECT data using a preconditioned alternating projection algorithm
Theoretical Study of Penalized-Likelihood Image Reconstruction forRegion of Interest Quantification