The study of human mutation rates

Technical Report · Wed Jan 01 00:00:00 EST 1992

DOI:https://doi.org/10.2172/7175958· OSTI ID:7175958

Neel, J V

We will describe recent developments regarding the question of induced mutations in the survivors of the atomic bombings of Hiroshima and Nagasaki. As part of that work we, describe some developments with respect to the Amerindian blood samples collected under DoE sponsorship between 1964 and 1982. Then developments regarding the application of two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) to the study of genetic variation and mutation affecting protein characteristics. In particular, we will report on the identification and isolation of genes of especial interest as reflected in the behavior of the proteins which they encode.

• Research Organization: Univ. of Michigan, Ann Arbor, MI (United States)
• Sponsoring Organization: USDOE; USDOE, Washington, DC (United States)
• DOE Contract Number: FG02-87ER60533
• OSTI ID: 7175958
• Report Number(s): DOE/ER/60533-5; ON: DE93003658; TRN: 92-038159
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
AMERICAN INDIANS
GENETIC VARIABILITY
GENE MUTATIONS
MUTATION FREQUENCY
GLOBULINS
A-BOMB SURVIVORS
AMINO ACID SEQUENCE
BLOOD SERUM
ELECTROPHORESIS
GENETIC RADIATION EFFECTS
HEREDITARY DISEASES
HYDROXYLASES
MAN
NUCLEOPROTEINS
PHOSPHORUS 32
PHOSPHOTRANSFERASES
PROGRESS REPORT
PROTEIN STRUCTURE
RISK ASSESSMENT
VIRAL DISEASES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL VARIABILITY
DAYS LIVING RADIOISOTOPES
DISEASES
DOCUMENT TYPES
ENZYMES
GENETIC EFFECTS
HUMAN POPULATIONS
INFECTIOUS DISEASES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINORITY GROUPS
MOLECULAR STRUCTURE
MUTATIONS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PHOSPHORUS ISOTOPES
PHOSPHORUS-GROUP TRANSFERASES
POPULATIONS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIOISOTOPES
TRANSFERASES
VERTEBRATES
560151* - Radiation Effects on Animals- Man
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man
550400 - Genetics
550201 - Biochemistry- Tracer Techniques