Clinical results of stereotactic heavy-charged-particle radiosurgery for intracranial angiographically occult vascular malformations

Conference · Fri Dec 01 00:00:00 EST 1989

OSTI ID:7001525

Levy, R P; Fabrikant, J I; Phillips, M H; Frankel, K A; Steinberg, G K; Marks, M P; DeLaPaz, R L; Chuang, F Y.S.; Lyman, J T

Angiographically occult vascular malformations (AOVMs) of the brain have been recognized for many years to cause neurologic morbidity and mortality. They generally become symptomatic due to intracranial hemorrhage, focal mass effect, seizures or headaches. The true incidence of AOVMs is unknown, but autopsy studies suggest that they are more common than high-flow angiographically demonstrable arteriovenous malformations (AVMs). We have developed stereotactic heavy-charged-particle Bragg peak radiosurgery for the treatment of inoperable intracranial vascular malformations, using the helium ion beams at the Lawrence Berkeley Laboratory 184-inch Synchrocyclotron and Bevatron. This report describes the protocol for patient selection, radiosurgical treatment planning method, clinical and neuroradiologic results and complications encountered, and discusses the strengths and limitations of the method. 10 refs., 1 fig.

• Research Organization: Lawrence Berkeley Lab., CA (USA)
• Sponsoring Organization: DOE/ER
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 7001525
• Report Number(s): LBL-28254; CONF-8905227-5; ON: DE90007756; TRN: 90-007958
• Resource Relation: Conference: International conference on radiosurgery a neurosurgical approach to intracranial lesions, Charlottesville, VA (USA), 1-5 May 1989
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARTERIES
MALFORMATIONS
RADIOTHERAPY
VASCULAR DISEASES
BIOLOGICAL REPAIR
VEINS
BIOLOGICAL RADIATION EFFECTS
BRAIN
CHARGED PARTICLES
CHARGED-PARTICLE REACTIONS
HEMORRHAGE
MORTALITY
NEUROLOGY
PATIENTS
RADIATION DOSES
RADIOBIOLOGY
SURGERY
THERAPEUTIC USES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGY
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CENTRAL NERVOUS SYSTEM
DISEASES
DOSES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEAR REACTIONS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOLOGY
RECOVERY
REPAIR
SYMPTOMS
THERAPY
USES
550603* - Medicine- External Radiation in Therapy- (1980-)
560152 - Radiation Effects on Animals- Animals
560100 - Biomedical Sciences
Applied Studies- Radiation Effects