Biological markers in animals can provide information on exposure and bioavailability of environmental contaminants

Conference · Thu Jan 01 00:00:00 EST 1987

OSTI ID:6936370

Shugart, L R; Adams, S M; Jimenez, B D; Talmage, S S; McCarthy, J F

Epidemiologic studies of agents present in the environment seek to identify the extent to which they contribute to the causation of a specific toxic, clinical, or pathological endpoint. The multifactorial nature of disease etiology, long latency periods and the complexity of exposure, all contribute to the difficulty of establishing associations and casual relationships between a specific exposure and an adverse outcome. These barriers to studies of exposures and subsequent risk assessment cannot generally be changed. However, the appropriate use of biological markers in animal species living in a contaminated habitat can provide a measure of potential damage from that exposure and, in some instances, act as a surrogate for human environmental exposures. Quantitative predictivity of the effect of exposure to environmental pollutants is being approached by employing an appropriate array of biological end points. 34 refs., 1 fig., 6 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400; AC05-84OS21400
• OSTI ID: 6936370
• Report Number(s): CONF-8708254-1; ON: DE88010467
• Resource Relation: Conference: Symposium on chemical basis for biological monitoring, New Orleans, LA, USA, 30 Aug 1987
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL MARKERS
USES
HAZARDOUS MATERIALS
RISK ASSESSMENT
BENZOPYRENE
BIOLOGICAL EFFECTS
DNA ADDUCTS
ENVIRONMENTAL EXPOSURE PATHWAY
ENZYME ACTIVITY
HUMAN POPULATIONS
INDUCTION
INFORMATION NEEDS
NEOPLASMS
POLLUTANTS
TOXICITY
ADDUCTS
AROMATICS
CONDENSED AROMATICS
DISEASES
HYDROCARBONS
MATERIALS
ORGANIC COMPOUNDS
POPULATIONS
560300* - Chemicals Metabolism & Toxicology