Practical simplifications for radioimmunotherapy dosimetric models
- Univ. of California, Sacramento, CA (United States). Davis Medical Center
Radiation dosimetry is potentially useful for assessment and prediction of efficacy and toxicity for radionuclide therapy. The usefulness of these dose estimates relies on the establishment of a dose-response model using accurate pharmacokinetic data and a radiation dosimetric model. Due to the complexity in radiation dose estimation, many practical simplifications have been introduced in the dosimetric modeling for clinical trials of radioimmunotherapy. Although research efforts are generally needed to improve the simplifications used at each stage of model development, practical simplifications are often possible for specific applications without significant consequences to the dose-response model. In the development of dosimetric methods for radioimmunotherapy, practical simplifications in the dosimetric models were introduced. This study evaluated the magnitude of uncertainty associated with practical simplifications for: (1) organ mass of the MIRD phantom; (2) radiation contribution from target alone; (3) interpolation of S value; (4) macroscopic tumor uniformity; and (5) fit of tumor pharmacokinetic data.
- Research Organization:
- Oak Ridge Associated Universities, TN (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States); National Cancer Inst., Bethesda, MD (United States)
- DOE Contract Number:
- FG03-84ER60233
- OSTI ID:
- 684483
- Report Number(s):
- ORISE-99-0164-Vol.1; CONF-960536-PROC.-Vol.1; ON: DE99002903; TRN: IM9943%%174
- Resource Relation:
- Conference: 6. international radiopharmaceutical dosimetry symposium, Gatlinburg, TN (United States), 7-10 May 1996; Other Information: PBD: Jan 1999; Related Information: Is Part Of Sixth international radiopharmaceutical dosimetry symposium: Proceedings. Volume 1; S.-Stelson, A.T. [ed.] [comp.]; Stabin, M.G.; Sparks, R.B. [eds.]; Smith, F.B. [comp.]; PB: 386 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dosimetric evaluation for radioimmunotherapy of Cu-64-2IT-BAT-LYM-1 radiocontaminant in Cu-67-2IT-BAT-LYM-1 radiopharmaceutical
Dosimetric evaluation of copper-64 in copper-67-2IT-BAT-Lym-1 for radioimmunotherapy