Temporal aspects of tumorigenic response to individual and mixed carcinogens. Comprehensive progress report, June 1, 1975--May 31, 1978. [Mouse skin, rats, hamsters]
The research proposed here is designed to obtain a better understanding of the temporal kinetics of tumor induction when one or more carcinogens are present simultaneously or sequentially for prolonged periods of time. Studies done to date under this contract have shown that carcinogenesis in mouse skin by polycyclic aromatic hydrocarbon carcinogens is consistent with the induction of dependent and autonomous cell transformations by the carcinogen followed by the conversion of autonomous tumor cells into malignancies at a rate which is determined by the level of carcinogen exposure. Dependent cell transformations remain latent in the skin unless expressed by a promoting agent. Dependent neoplasia appears to follow one-hit kinetics while malignancy is a multihit endpoint. Dose-related and time-related aspects of tumor induction are separable in the initiation-promotion system of mouse skin which along with rat skin and hamster lung is being used as a model for testing hypotheses. Results to date provide the basis for a new interpretation of the linear non-threshold extrapolation model. The broad aim of the study is to provide a basis or rationale for estimating risks associated with prolonged exposures to carcinogens found in the environment and to predict how different tissues and species respond to the same carcinogens.
- Research Organization:
- New York Univ., N.Y. (USA). Inst. of Environmental Medicine
- DOE Contract Number:
- EY-76-S-02-2737
- OSTI ID:
- 6787045
- Report Number(s):
- COO-2737-7
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOGENS
BIOLOGICAL EFFECTS
NEOPLASMS
KINETICS
SKIN
TUMOR CELLS
MORPHOLOGICAL CHANGES
DOSE-RESPONSE RELATIONSHIPS
HAMSTERS
HAZARDS
MICE
RATS
ANIMAL CELLS
ANIMALS
BODY
DISEASES
MAMMALS
ORGANS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)