Nuclear medicine technology progress report for quarter ending June 30, 1978. ABELLED COMPOUNDS; PATIENTS; POSITRON SOURCES; CARBON 11; ISOMERIC NUCLEI; LABELLED COMPOUNDS; BIOLOGICAL LOCALIZATION; CHEMICAL PREPARATION; ISOMERIC NUCLEI; LABELLED COMPOUNDS; RATS; CHEMICAL PREPARATION; LABELLED COMPOUNDS; RATS; TISSUE DISTRIBUTION
Progress is reported for the applications of /sup 11/C, /sup 195m/Pt, /sup 75/Se, and /sup 123m/Te. Additional human clinical trials with /sup 11/C-DL-tryptophan and /sup 11/C-l-aminocyclobutane carboxylic acid have been completed. The modified Buecherer-Strecker amino acid synthesis has been used to prepare /sup 11/C-DL-phenylglycine and /sup 11/C-DL-phenylalanine. These two new /sup 11/C-labeled amino acids will be studied as potential tumor localizing agents. Preliminary studies concerning the comparative organ and subcellular distribution of /sup 195m/Pt-labeled cis- and trans- dichlorodiamineplatinum(II) have been completed. The results of in vivo studies have shown the cis isomer to bind to nuclear DNA to a significantly greater extent than the trans isomer. A series of /sup 123m/Te-labeled long-chain fatty acid analogs have been prepared as isosteres of unsaturated fatty acids. Several of these compounds show pronounced heart uptake in rats and may represent a new class of potential myocardial imaging agents. Studies on the preparation and tissue distribution of /sup 75/Se-..beta..-aminoethyl selenosulfate continue.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 6777220
- Report Number(s):
- ORNL/TM-6638; TRN: 79-003273
- Country of Publication:
- United States
- Language:
- English
Similar Records
Nuclear medicine technology. Progress report, quarter ending March 31, 1980
Nuclear medicine technology progress report for quarter ending March 31, 1978
Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
CARBON 11
CAT SCANNING
RADIOPHARMACEUTICALS
CARBOXYLIC ACID ESTERS
NEOPLASMS
DIAGNOSIS
PANCREAS
BIOLOGICAL LOCALIZATION
TRYPTOPHAN
AMINO ACIDS
PHENYLALANINE
CHEMICAL PREPARATION
ORGANIC CHLORINE COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANOMETALLIC COMPOUNDS
PLATINUM 195
PLATINUM COMPOUNDS
TISSUE DISTRIBUTION
CARBOXYLIC ACIDS
MYOCARDIUM
SCINTISCANNING
TELLURIUM 123
SELENIUM 75
SELENIUM COMPOUNDS
SULFURIC ACID ESTERS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ESTERS
EVEN-ODD NUCLEI
GLANDS
HEART
HEAVY NUCLEI
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDOLES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PARTICLE SOURCES
PHOTON TRANSMISSION SCANNING
PLATINUM ISOTOPES
PYRROLES
RADIATION SOURCES
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RODENTS
SELENIUM ISOTOPES
STABLE ISOTOPES
SYNTHESIS
TELLURIUM ISOTOPES
TOMOGRAPHY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)
400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials