Deletions, duplications and transpositions of the COR segment that encompasses the structural gene of yeast iso-1-cytochrome c
It has been recently found that a specific chromosomal segment, in certain but not all laboratory strains of Saccharomyces cerevisiae, is deleted and transposed at high frequencies. This segment, denoted COR, encompasses the three closely linked loci CYC1, OSM1 and RAD7 which control iso-1-cytochrome c, osmotic sensitivity and UV-sensitivity, respectively. Two types of apparently normal laboratory strains of yeast designated COR1 and COR2, were uncovered after the examination of the frequencies and types of mutations causing either deficiencies or overproduction of iso-1-cytochrome c; in contrast to COR1 strains which give predominantly point mutations causing deficiencies of iso-1-cytochrome c, COR2 strains give rise to deletions and transpositions of the COR segment. We have undertaken a systematic investigation of the physical structure and genetic properties of the COR region and of the aberrations arising in COR2 strains.
- Research Organization:
- Rochester Univ., NY (USA). School of Medicine and Dentistry; Indiana State Univ., Terre Haute (USA). Dept. of Life Sciences
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 6774099
- Report Number(s):
- UR-3490-1871; CONF-800595-2
- Resource Relation:
- Conference: Cold Spring Harbor symposium No. 45: movable genetic elements, Cold Spring Harbor, NY, USA, 28 May 1980
- Country of Publication:
- United States
- Language:
- English
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