Design and evaluation of radiotracers for determination of regional cerebral blood flow with PET

Conference · Fri Jan 01 00:00:00 EST 1982

OSTI ID:6607740

Lambrecht, R M; Duncan, C C; Shiue, C Y

The tracer kinetics of 4-Fluoro(/sup 18/F)-, 4-Bromo(/sup 82/Br)- and 4-Iodo(/sup 125/I)-antipyrine and /sup 15/O-water were compared in a cat or baboon animal model. First-pass cerebral extraction and clearance with alterations in PaCO/sub 2/ were measured for whole brain. The Renkin/Crone model was used to evaluate brain capillary permeability-surface area product for 4-/sup 18/FAP in cats. Positron-emission-tomographic measurements required development of an instrument and technique for control of the arterial concentration of the radiotracer as a ramp function, so that tracer concentration changes due to radioactive decay or altered physiological processes could be accurately described with PET. Pharmacokinetic and tissue-distribution studies in cats were used to determine dosimetry for 4-/sup 18/FAP. 4-Bromoantipyrine labeled with /sup 78/Br (t = 6.5 m) is suggested as a tracer for determination of rCBF with PET.

• Research Organization: Brookhaven National Lab., Upton, NY (USA); Yale Univ., New Haven, CT (USA). School of Medicine
• DOE Contract Number: AC02-76CH00016
• OSTI ID: 6607740
• Report Number(s): BNL-32297; CONF-820804-3; ON: DE83004582
• Resource Relation: Conference: 3. world congress of nuclear medicine and biology, Paris, France, 29 Aug 1982; Other Information: Portions of document are illegible
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
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RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
CEREBRUM
BLOOD FLOW
FLUORINE 18
IODINE 125
OXYGEN 15
DESIGN
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BRAIN
CATS
DYNAMIC FUNCTION STUDIES
POSITRON COMPUTED TOMOGRAPHY
RADIONUCLIDE KINETICS
TRACER TECHNIQUES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
BROMINE ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
TOMOGRAPHY
VERTEBRATES
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