Specific allogeneic unresponsiveness in the adult host: present-day experimental models
As part of a long-term intensive effort to apply the induction of adult allogensic unresponsiveness to the transplantation problem, two techniques to control the variability in the persistence of immunologically competent postthymic cells iin the treated host and/or the inoculum of autologous marrow returned to the host after irradiation are described. The first consisted of exposing the peripheral blood of prospective recipients to a 5-week course of extra-corporeal irradiation (ECIB), the other of exposing the stored autologous marrow scheduled to repopulate a given recipient to methyl-prednisolone (MPd) and DNase prior to renifusion into the recipient. Serial analysis of bone marrow cell samples at various intervals before and after treatment was undertaken. The significance of the disappearance of a particular population of nonnuclear cells from the samples, and the association of such disappearance with increased success in the induction of allogeneic unresponsiveness is discussed. (ACR)
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA); State Univ. of New York, Stony Brook (USA). Dept. of Surgery
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 6602550
- Report Number(s):
- BNL-32201; CONF-8206135-1; ON: DE83003946
- Resource Relation:
- Conference: 8. international congress of the Transplantation Society, Boston, MA, USA, 29 Jun 1982; Other Information: Portions of document are illegible
- Country of Publication:
- United States
- Language:
- English
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