Relative potency as a means of evaluating ELF (Extremely Low Frequency) health risks
Abstract
In the 1970's, a variety of developments took place to heightened public and scientific interest in electromagnetic fields. During this time, biological studies of nonionizing electromagnetic fields were taking place, but no clear evidence of risks to public health was identified. Then came the surprising epidemiological finding suggesting that 60 Hz magnetic fields may be related to some childhood leukemias. Our particular interest at ORNL was how to interpret the available data with respect to human exposures to the nearly ubiquitous fields. A review of the available data showed that consistent biological effects were difficult to identify. Classical toxicological tests used in chemical risk assessment had not been performed with Extremely Low Frequency (ELF) fields but rather a wide range of mechanistic studies had been pursued. To evaluate the level of anticipated hazard or risk there was neither a mechanistic understanding nor a consistent phenomenological outcome. A risk evaluation normally requires one or the other of these two types of information. Two quite different approaches were pursued: meta-analysis and relative potency. The first of these is a method to combine data from similar experiments to enhance the relative statistical power of a collection of small sample size studies, and willmore »
- Authors:
- Publication Date:
- Research Org.:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Org.:
- DOE/ER
- OSTI Identifier:
- 6551772
- Report Number(s):
- CONF-9009221-4
ON: DE91000727
- DOE Contract Number:
- AC05-84OR21400
- Resource Type:
- Conference
- Resource Relation:
- Conference: 6. international symposium on gaseous dielectrics, Knoxville, TN (USA), 23-27 Sep 1990
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHRONIC EXPOSURE; HEALTH HAZARDS; ELECTROMAGNETIC FIELDS; BIOLOGICAL EFFECTS; ACETYLCHOLINE; CARCINOGENS; CHILDREN; EPIDEMIOLOGY; HUMAN POPULATIONS; LEUKEMIA; PUBLIC HEALTH; RISK ASSESSMENT; TOXICITY; AGE GROUPS; AMINES; AMMONIUM COMPOUNDS; AUTONOMIC NERVOUS SYSTEM AGENTS; DISEASES; DRUGS; ESTERS; HAZARDS; HEMIC DISEASES; IMMUNE SYSTEM DISEASES; NEOPLASMS; NEUROREGULATORS; ORGANIC COMPOUNDS; PARASYMPATHOMIMETICS; POPULATIONS; QUATERNARY COMPOUNDS; 560400* - Other Environmental Pollutant Effects
Citation Formats
Easterly, C E, and Glass, L R. Relative potency as a means of evaluating ELF (Extremely Low Frequency) health risks. United States: N. p., 1990.
Web.
Easterly, C E, & Glass, L R. Relative potency as a means of evaluating ELF (Extremely Low Frequency) health risks. United States.
Easterly, C E, and Glass, L R. 1990.
"Relative potency as a means of evaluating ELF (Extremely Low Frequency) health risks". United States. https://www.osti.gov/servlets/purl/6551772.
@article{osti_6551772,
title = {Relative potency as a means of evaluating ELF (Extremely Low Frequency) health risks},
author = {Easterly, C E and Glass, L R},
abstractNote = {In the 1970's, a variety of developments took place to heightened public and scientific interest in electromagnetic fields. During this time, biological studies of nonionizing electromagnetic fields were taking place, but no clear evidence of risks to public health was identified. Then came the surprising epidemiological finding suggesting that 60 Hz magnetic fields may be related to some childhood leukemias. Our particular interest at ORNL was how to interpret the available data with respect to human exposures to the nearly ubiquitous fields. A review of the available data showed that consistent biological effects were difficult to identify. Classical toxicological tests used in chemical risk assessment had not been performed with Extremely Low Frequency (ELF) fields but rather a wide range of mechanistic studies had been pursued. To evaluate the level of anticipated hazard or risk there was neither a mechanistic understanding nor a consistent phenomenological outcome. A risk evaluation normally requires one or the other of these two types of information. Two quite different approaches were pursued: meta-analysis and relative potency. The first of these is a method to combine data from similar experiments to enhance the relative statistical power of a collection of small sample size studies, and will not be discussed further. The second, relative potency, will be the focus of this paper. 20 refs., 2 figs.},
doi = {},
url = {https://www.osti.gov/biblio/6551772},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Sat Sep 01 00:00:00 EDT 1990},
month = {Sat Sep 01 00:00:00 EDT 1990}
}