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Title: Integrated separation and optical detection for novel on-chip chemical analysis

Abstract

This report represents the completion of a two years Laboratory Directed Research and Development (LDRD) program to investigate miniaturized systems for chemical detection and analysis. The future of advanced chemical detection and analysis is in miniature devices that are able to characterize increasingly complex samples, a laboratory on a chip. In this concept, chemical operations used to analyze complicated samples in a chemical laboratory sample handling, species separation, chemical derivitization and detection are incorporated into a miniature device. By using electrokinetic flow, this approach does not require pumps or valves, as fluids in microfabricated channels can be driven by externally applied voltages. This is ideal for sample handling in miniature devices. This project was to develop truly miniature on-chip optical systems based on Vertical Cavity Surface Emitting Lasers (VCSELs) and diffractive optics. These can be built into a complete system that also has on-chip electrokinetic fluid handling and chemical separation in a microfabricated column. The primary goal was the design and fabrication of an on-chip separation column with fluorescence sources and detectors that, using electrokinetic flow, can be used as the basis of an automated chemical analysis system. Secondary goals involved investigation of a dispersed fluorescence module that can bemore » used to extend the versatility of the basic system and on chip, intracavity laser absorption as a high sensitivity detection technique.« less

Authors:
; ; ;
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE, Washington, DC (United States)
OSTI Identifier:
650144
Report Number(s):
SAND-98-0509
ON: DE98003407; TRN: AHC2DT04%%55
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Technical Report
Resource Relation:
Other Information: PBD: Mar 1998
Country of Publication:
United States
Language:
English
Subject:
40 CHEMISTRY; 42 ENGINEERING NOT INCLUDED IN OTHER CATEGORIES; MINIATURIZATION; MEASURING INSTRUMENTS; CHEMICAL ANALYSIS; MICROELECTRONIC CIRCUITS; FLUORESCENCE SPECTROSCOPY; DESIGN; FABRICATION; ELECTROPHORESIS

Citation Formats

Warren, M E, Anex, D S, Rakestraw, D, and Gourley, P L. Integrated separation and optical detection for novel on-chip chemical analysis. United States: N. p., 1998. Web. doi:10.2172/650144.
Warren, M E, Anex, D S, Rakestraw, D, & Gourley, P L. Integrated separation and optical detection for novel on-chip chemical analysis. United States. https://doi.org/10.2172/650144
Warren, M E, Anex, D S, Rakestraw, D, and Gourley, P L. 1998. "Integrated separation and optical detection for novel on-chip chemical analysis". United States. https://doi.org/10.2172/650144. https://www.osti.gov/servlets/purl/650144.
@article{osti_650144,
title = {Integrated separation and optical detection for novel on-chip chemical analysis},
author = {Warren, M E and Anex, D S and Rakestraw, D and Gourley, P L},
abstractNote = {This report represents the completion of a two years Laboratory Directed Research and Development (LDRD) program to investigate miniaturized systems for chemical detection and analysis. The future of advanced chemical detection and analysis is in miniature devices that are able to characterize increasingly complex samples, a laboratory on a chip. In this concept, chemical operations used to analyze complicated samples in a chemical laboratory sample handling, species separation, chemical derivitization and detection are incorporated into a miniature device. By using electrokinetic flow, this approach does not require pumps or valves, as fluids in microfabricated channels can be driven by externally applied voltages. This is ideal for sample handling in miniature devices. This project was to develop truly miniature on-chip optical systems based on Vertical Cavity Surface Emitting Lasers (VCSELs) and diffractive optics. These can be built into a complete system that also has on-chip electrokinetic fluid handling and chemical separation in a microfabricated column. The primary goal was the design and fabrication of an on-chip separation column with fluorescence sources and detectors that, using electrokinetic flow, can be used as the basis of an automated chemical analysis system. Secondary goals involved investigation of a dispersed fluorescence module that can be used to extend the versatility of the basic system and on chip, intracavity laser absorption as a high sensitivity detection technique.},
doi = {10.2172/650144},
url = {https://www.osti.gov/biblio/650144}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Sun Mar 01 00:00:00 EST 1998},
month = {Sun Mar 01 00:00:00 EST 1998}
}