Interspecific comparisons of the sensitivity to chromosome aberration production by x rays. [Comparative in vitro radiosensitivity of leukocyte chromosomes from mice to man]

Conference · Sun Jan 01 00:00:00 EST 1978

OSTI ID:6392304

Brewen, J G

It is concluded that arm number probably plays a minor role, if any, in the relative radiosensitivity of a species. Instead the reported differences are probably a reflection of inherent basic biological mechanisms of repair that vary from one order of mammals to the next. It should be added, however, that the ultimate goal of all of these studies is to make a reasonable risk estimate for man. In that context the best approach is that of conservatism and the current data on mouse and man suggest that man has 1.5 to 2.0 times the risk of mice for chromosome rearrangement induction by x rays.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 6392304
• Report Number(s): CONF-781090-1; TRN: 79-008179
• Resource Relation: Conference: Workshop on radiation-induced chromosome oberrations for genetic risk evaluation in man, Edinburgh, UK, 23 Oct 1978
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHROMOSOMAL ABERRATIONS
RADIOINDUCTION
CHROMOSOMES
RADIOSENSITIVITY
LEUKOCYTES
MAN
MICE
COMPARATIVE EVALUATIONS
BIOLOGICAL RADIATION EFFECTS
IN VITRO
IRRADIATION
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
ELECTROMAGNETIC RADIATION
IONIZING RADIATIONS
MAMMALS
MUTATIONS
PRIMATES
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560151* - Radiation Effects on Animals- Man
560152 - Radiation Effects on Animals- Animals