Inhalation toxicology of diesel fuel obscurant aerosol in Sprague-Dawley rats. Final report, Phase 3, subchronic exposures
Inhalation exposures were performed twice per week, for 13 weeks, to determine whether there was any potential toxicity to rats of comparatively low concentrations of a condensation aerosol from diesel fuel. Changes in breathing frequency and the response of animals to a loud sharp sound (startle response) were measured in selected animals prior to the start of the exposures, at various time points during the thirteen week exposure period, and at monthly intervals during the recovery period. Assays were performed on selected animals at the end of the exposure period, and again after the two month recovery period. Endpoints included pulmonary function tests, numbers of alveolar free cells, clinical chemistry, hematology, organ weights and histopathology. No mortalities were recorded during the exposure or recovery periods. Slight toxicity occurred at these low aerosol concentrations with the loss in body weight of all treated animals during the exposure period. During the exposure period there were also some slight changes in startle reflex, however, these were apparently acute effects, and there appeared to be no permanent CNS involvement as measured by this endpoint. Immediately post-exposure, the numbers of lavaged alveolar macrophages were slightly elevated in all aerosol exposed animals. Pulmonary function tests, pulmonary gas exchange and dynamic lung tests were all apparently unaffected by these low diesel fuel aerosol exposures. Changes in tissue weights in aerosol exposed animals were minor and the few histopathological lesions were randomly scattered amongst all groups included in this study and were more attributable to the age of the animals than any specific treatment group. No significant cumulative toxicity may be attributed to these diesel fuel aerosol exposures. 14 references, 1 figure, 42 tables.
- Research Organization:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6151812
- Report Number(s):
- ORNL/TM-9403; ON: DE85005336
- Country of Publication:
- United States
- Language:
- English
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Inhalation toxicology of diesel-fuel obscurant aerosol in Sprague-Dawley rats. Chemical characterization and toxicological evaluation of airborne mixtures. Final report, phase 1, acute exposure
A SUBCHRONIC INHALATION STUDY OF FISCHER 344 RATS EXPOSED TO 0, 0.4, 1.4 OR 4.0 PPM ACROLEIN.
Related Subjects
DIESEL FUELS
TOXICITY
AEROSOLS
BEHAVIOR
BIOLOGICAL FUNCTIONS
CHRONIC EXPOSURE
EXPERIMENTAL DATA
INHALATION
LUNGS
MORTALITY
RATS
ANIMALS
BODY
COLLOIDS
DATA
DISPERSIONS
FUNCTIONS
INFORMATION
INTAKE
MAMMALS
NUMERICAL DATA
ORGANS
PETROLEUM PRODUCTS
RESPIRATORY SYSTEM
RODENTS
SOLS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)