Division of Biological and Medical Research annual technical report 1982

Technical Report · Sun May 01 00:00:00 EDT 1983

DOI:https://doi.org/10.2172/5949869· OSTI ID:5949869

Rosenthal, M W ^[1]

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1. ed.

This report summarizes research during 1982 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Carcinogenesis address mechanisms of chemical and radiation carcinogenesis including the processes of tumor initiation and promotion. The studies employ rat liver and mouse skin models as well as human rodent cell culture systems. The use of liposomes for metal mobilization is also explored. Low Level Radiation studies include delineation of the hematopoietic and other responses of dogs to continuous low level gamma irradiation, comparison of lifetime effects in mice of low level neutron and gamma irradiation, and study of the genetic effects of high LET radiation. Molecular Biology research develops two-dimensional electrophoresis systems for diagnosis and detection of cancer and other diseases. Fundamental structural and biophysical investigations of immunoglobulins and other key proteins are included, as are studies of cell growth, and of molecular and cellular effects of solar uv light. Research in Toxicology uses cellular, physiological, whole animal, and chronobiological end points and chemical separations to elucidate mechanisms and evaluate hazards of coal conversion by-products, actinides, and toxic metals. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.

• Research Organization: Argonne National Lab. (ANL), Argonne, IL (United States)
• DOE Contract Number: W-31-109-ENG-38
• OSTI ID: 5949869
• Report Number(s): ANL-83-40; ON: DE83015756
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANL
RESEARCH PROGRAMS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
MOLECULAR BIOLOGY
TOXICITY
ACTINIDES
BIOLOGICAL MODELS
BLOOD FORMATION
CELL CULTURES
COAL LIQUIDS
DIAGNOSTIC TECHNIQUES
ELECTROPHORESIS
GAMMA RADIATION
IMMUNOGLOBULINS
LET
LIPOSOMES
LOW DOSE IRRADIATION
METALS
MOLECULAR STRUCTURE
NEUTRONS
ULTRAVIOLET RADIATION
BARYONS
BIOLOGICAL EFFECTS
CELL CONSTITUENTS
ELECTROMAGNETIC RADIATION
ELEMENTARY PARTICLES
ELEMENTS
ENERGY TRANSFER
FERMIONS
FLUIDS
GLOBULINS
HADRONS
IONIZING RADIATIONS
IRRADIATION
LIQUIDS
NATIONAL ORGANIZATIONS
NUCLEONS
ORGANIC COMPOUNDS
ORGANOIDS
PATHOGENESIS
PROTEINS
RADIATION EFFECTS
RADIATIONS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
560152* - Radiation Effects on Animals- Animals
560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)