Absorption, distribution and excretion of inhaled hydrogen fluoride in the rat
Rats were subjected to whole body HF exposure for 6 hrs or to nose-only HF exposure for 1 hr. Total and/or ionic fluoride concentrations in selected tissues were determined at various times following exposure. In rats sacrificed 6 hrs after whole body exposure, dose-dependent increases in lung, plasma, and kidney total and ionic fluoride concentration occurred. Rats excreted more fluoride in the urine after whole body exposure than could be explained by the amount of HF inhaled. Considerable evidence suggests that airborne HF deposits on fur and is then ingested due to preening activity. Urinary fluoride excretion was increased by nose-only exposure. The urinary fluoride excretion accounted for approximately twice the fluoride estimated to be inhaled during exposure. Tissue fluoride concentrations were elevated immediately after nose-only exposure. Fluoride concentrations in lung and kidney returned to control levels within 12 hrs. Plasma fluoride concentration was slightly elevated 24 hrs after the start of the 1 hr exposure but was at control levels at 96 hrs. Immediately following nose-only exposure, lung ionic fluoride concentrations were less than plasma ionic fluoride concentrations suggesting that the fluoride in the lung had reached that site via plasma transport rather than by inhalation. A dose-dependent increase in plasma ionic fluoride concentration occurred after upper respiratory tract HF exposure providing strong evidence that fluoride is absorbed systemically from that site. The plasma ionic fluoride concentration after upper respiratory tract exposure was of sufficient magnitude to account for the plasma fluoride concentrations observed in intact nose-only exposed rats. (ERB)
- Research Organization:
- Rochester Univ., NY (USA). Dept. of Radiation Biology and Biophysics
- DOE Contract Number:
- EY-76-C-02-3490
- OSTI ID:
- 5929675
- Report Number(s):
- UR-3490-1658
- Resource Relation:
- Other Information: Thesis
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
54 ENVIRONMENTAL SCIENCES
HYDROFLUORIC ACID
BIOLOGICAL LOCALIZATION
EXCRETION
TISSUE DISTRIBUTION
AEROSOLS
BLOOD PLASMA
EXPERIMENTAL DATA
EXPOSURE CHAMBERS
FECES
FEMUR
INHALATION
ISOLATED VALUES
KIDNEYS
LUNGS
RATS
RESPIRATORY SYSTEM
TRACHEA
URINE
ANIMALS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD
BODY
BODY FLUIDS
CLEARANCE
COLLOIDS
DATA
DATA FORMS
DISPERSIONS
DISTRIBUTION
HYDROGEN COMPOUNDS
INFORMATION
INORGANIC ACIDS
INTAKE
MAMMALS
NUMERICAL DATA
ORGANS
RODENTS
SKELETON
SOLS
VERTEBRATES
WASTES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
500200 - Environment
Atmospheric- Chemicals Monitoring & Transport- (-1989)