The relationship of bone and blood lead to hypertension: Further analyses of the normative aging study data
- Harvard Medical School, Boston, MA (United States)
- Harvard School of Public Health, Boston, MA (United States); and others
In an earlier report based on participants in the Veterans Administration Normative Aging Study, we found a significant association between the risk of hypertension and lead levels in tibia. To examine the possible confounding effects of education and occupation, we considered in this study five levels of education and three levels of occupation as independent variables in the statistical model. Of 1,171 active subjects seen between August 1991 and December 1994, 563 provided complete data for this analysis. In the initial logistic regression model, acre and body mass index, family history of hypertension, and dietary sodium intake, but neither cumulative smoking nor alcohol ingestion, conferred increased odds ratios for being hypertensive that were statistically significant. When the lead biomarkers were added separately to this initial logistic model, tibia lead and patella lead levels were associated with significantly elevated odds ratios for hypertension. In the final backward elimination logistic regression model that included categorical variables for education and occupation, the only variables retained were body mass index, family history of hypertension, and tibia lead level. We conclude that education and occupation variables were not confounding the association between the lead biomarkers and hypertension that we reported previously. 27 refs., 3 tabs.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- OSTI ID:
- 567739
- Report Number(s):
- CONF-9611157-; ON: DE97009015; CNN: Grant 2 P30 ES 00002; TRN: 98:000722-0036
- Resource Relation:
- Journal Volume: 275; Journal Issue: 15; Conference: 1996 Pacific Basin conference on hazardous waste, Kuala Lumpur (Malaysia), 4-8 Nov 1996; Other Information: PBD: [1996]; Related Information: Is Part Of Pacific Basin conference on hazardous waste: Proceedings; PB: 706 p.
- Country of Publication:
- United States
- Language:
- English
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