Labeling of receptor ligands and other compounds with halogen radionuclides
- Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
Major advances have been made in all the areas. Specifically, patient studies have been carried out. This work has shown that the uptake of fluorine-18 labeled 16{alpha}-fluoroestradiol-17{beta} correlates well with receptor levels measured in vivo and also that the uptake of the tracer is blocked in humans by the administration of the antiestrogen tamoxifen. An image from this work was designated Image of the Year by Dr. Wagner, Jr., following his summary of the 1987 Society of Nuclear Medicine Meeting. We have also evaluated the brain uptake of both estrogen and progesterone, and this work was awarded the Berson-Yalow Award from the Society of Nuclear Medicine in 1988. This publication represents a new application of radiolabeled sex hormones. Hines and coworkers have suggested that hormone levels in the brain are important for sexual differentiation of human behavior. We have shown that both 16{alpha}-(F-18)-fluoroestradiol-17{beta} and 21-(F-18)-fluoro-16{alpha}-ethyl-19-norprogesterone (FENP) accumulate in the hypothalamus and pituitary tissues of primates and humans; and in primates this uptake can be blocked by administration of nonradioactive competing ligands. This presents an opportunity for studying sex hormone receptors in mammalian brain.
- Research Organization:
- Washington Univ., St. Louis, MO (USA). Edward Mallinckrodt Inst. of Radiology
- Sponsoring Organization:
- DOE/ER
- DOE Contract Number:
- FG02-84ER60218
- OSTI ID:
- 5654837
- Report Number(s):
- DOE/ER/60218-6; ON: DE90000160
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
LIGANDS
LABELLING
RADIOPHARMACEUTICALS
BIOCHEMICAL REACTION KINETICS
AUTOMATION
PROGRESS REPORT
STABILITY
STRUCTURE-ACTIVITY RELATIONSHIPS
SYNTHESIS
DOCUMENT TYPES
DRUGS
KINETICS
LABELLED COMPOUNDS
REACTION KINETICS
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550601 - Medicine- Unsealed Radionuclides in Diagnostics