History of attempts to quantify environmental mutagenesis
It became obvious in the early 1960's that the ready recognition of mutations produced by chemicals could have a profound influence on the refinement of methods to detect environmental mutagens. The experience derived over the previous 30 years in characterizing the effects of ionizing and ultraviolet radiation on the genetic mechanism came to serve us in good stead. Although the effects of chemicals are considerably more complicated and often require the analysis of individual substances, nonetheless, the area has developed rapidly in recent decades. The establishment and historical background of the International Association of Environmental Mutagen Societies (IAEMS) will be discussed. An attempt at the quantitation of chemical effects has been developed in comparison with radiation mutagenesis. As a first step, a definition of the Mutagen Burden or unavoidable exposure to chemicals will be discussed. A mathematical approach (Haynes/Eckhardt) will be considered and finally an outline for the comprehensive investigation of detailed interscience study will be made of less than six chemicals.
- Research Organization:
- Brookhaven National Lab., Upton, NY (USA); Associated Universities, Inc., Washington, DC (USA)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 5635008
- Report Number(s):
- BNL-30356; CONF-810992-3; ON: DE82005509
- Resource Relation:
- Conference: 3. international conference on environmental mutagens, Tokyo, Japan, 20 Sep 1981
- Country of Publication:
- United States
- Language:
- English
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