Synthetic crude oils carcinogenicity screening tests. Progress report, September 15, 1979-March 15, 1980

Technical Report · Tue Jan 01 00:00:00 EST 1980

DOI:https://doi.org/10.2172/5175565· OSTI ID:5175565

Calkins, W H; Deye, J F; King, C F; Hartgrove, R W; Krahn, D F

Four crude oils (H Coal-Fuel Oil Mode, Occidental in situ Shale Oil, Exxon Donor Solvent Liquid, and SRC II) which were distilled into four fractions (naphtha, mid-distillate, gas oil and residue) for analysis and biological screening testing during the last report period were tested for mutagenicity by the Ames test and for tumor initiating activity by an initiation/promotion (skin painting) test. Substantial agreement exists between Ames and skin painting results. Low boiling naphtha fractions of the 4 crude oils showed little or no mutagenicity or tumor initiating activity by the two tests used. The higher boiling fractions (gas oils and residues) and the crude oils themselves were mutagenic and exhibited tumor initiation activity. The coal derived fractions were more active by both tests than the shale oil fractions.

• Research Organization: Du Pont de Nemours (E.I.) and Co., Wilmington, DE (USA)
• DOE Contract Number: AC02-78EV10127
• OSTI ID: 5175565
• Report Number(s): COO-4758-3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
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COAL LIQUIDS
CARCINOGENESIS
PETROLEUM FRACTIONS
SHALE OIL
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MAMMALS
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PATHOGENESIS
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