Role of drosophila in chemical mutagenesis testing
An important question facing our society is the impact of numerous chemical insults on the health of man and his environment. Faced with a staggering array of chemicals and enormous testing costs, only a few chemicals can be tested for possible carcinogenic effects. Recent results with the Salmonella/mammalian microsome mutagenesis bioassay system demonstrate a striking correlation between carcinogenicity and mutagenicity of many chemical compounds and offer the possibility that mutagenesis assay systems can provide a quick identification of potential carcinogens. Results from microbial assays can serve as a guideline for further mutagenesis testing as well as identify those compounds requiring more extensive analysis in mammalian systems. Reliance on the results from a single mutagenic assay system is rather risky. It would be preferable to use a battery of tests (the tier approach) which would include the rapid microbial assays as well as mammalian systems. Also the use of Drosophila as a bridge between the microbial and mammalian assays has many desirable features which are discussed.
- Research Organization:
- Oak Ridge National Lab., Tenn. (USA)
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5133960
- Report Number(s):
- CONF-780227-1
- Resource Relation:
- Conference: Symposium on application of short-term bioassays in the fractionation and analysis of complex environmental mixtures, Williamsburg, VA, USA, 21 Feb 1978
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative mutagenesis. Progress report, January 1, 1977-December 31, 1977 (extended from January 1, 1978-December 31,1978
Energy-related pollutants in the environment: the use of short-term tests for mutagenicity in the isolation and identification of biohazards. [Escherichia coli, Salmonella, animal cells, Drosophila]
Related Subjects
DROSOPHILA
MUTAGENESIS
HAZARDOUS MATERIALS
BIOASSAY
ORGANIC COMPOUNDS
BIOLOGICAL EFFECTS
FRACTIONATION
SALMONELLA
CHEMICAL COMPOSITION
COMPARATIVE EVALUATIONS
ANIMALS
ARTHROPODS
BACTERIA
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
MICROORGANISMS
SEPARATION PROCESSES
560300* - Chemicals Metabolism & Toxicology
560304 - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)