Genetic and developmental study of a complex locus in the house mouse. Progress report, 1979-1980

Technical Report · Tue Jan 01 00:00:00 EST 1980

DOI:https://doi.org/10.2172/5073118· OSTI ID:5073118

Bennett, D.

More than 50 T/t-complex and other mouse chromosome variants have been maintained for genetic study, and for distribution to other investigators. Deletion mapping has been used to analyze a lethal t-haplotype, t/sup w73/, and has shown that the t/sup w73/ chromosome carries an additional parasitic lethal factor separate and different from the t-lethal factor. In other mapping experiments it was shown that the dominant mutation Kb (knobbly) is allelic to the previously described mutation Ki, although their embryonic lethal effects are different. Experiments to extract and analyze t-haplotypes from wild populations and to determine their H-2 types, as well as to characterize viable t-haplotypes produced by existing t-lethals have been continued.

• Research Organization: Sloan-Kettering Inst. for Cancer Research, New York (USA)
• DOE Contract Number: AS02-77EV04159
• OSTI ID: 5073118
• Report Number(s): COO-4159-6
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
MICE
GENETICS
ONTOGENESIS
GENETIC VARIABILITY
CHROMOSOMAL ABERRATIONS
DOMINANT MUTATIONS
GENES
GENETIC MAPPING
GENOTYPE
POPULATIONS
ANIMALS
BIOLOGICAL VARIABILITY
BIOLOGY
MAMMALS
MAPPING
MUTATIONS
RODENTS
VERTEBRATES
550400* - Genetics
551000 - Physiological Systems
550100 - Behavioral Biology