Radiation induction of cancer of the skin
The induction of epidermal tumors was studied using exposures to 25 kV x-rays with or without subsequent exposures to 12-0-tetradeconyl phorbol-13 acetate (TPA) or ultraviolet radiation (uvr) 280-400 nm. Fractionation regimens and total exposure up to 4000R produced no squamous cell carcinomas. When these regimes were followed by TPA an incidence of about 80% was obtained, and incidence of 60% when uvr exposures followed the x-irradiation. A dose-dependent increase in fibrosarcomas was found when x-irradiation was followed by 24 weeks of topical treatment with TPA. These results support the contention that uvr can enhance the expression of cells initiated by x-rays. The experimental evidence is compared with the data from the tinea capitis patients treated with x-rays. In C3HF/He male mice exposed to 50, 100, 150 and 200 rads /sup 137/Cs gamma rays the induction rate for fibrosarcomas was 2.9 x 10/sup -4/ per cGy/per mouse. This result compares with 2.5 x 10/sup -6/ transformations per surviving cell per cGy with 10T1/2 cells that are fibroblasts derived from C3H mice. 16 refs., 1 fig., 1 tab.
- Research Organization:
- Oak Ridge National Lab., TN (USA); New York Univ., NY (USA). Dept. of Environmental Medicine
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5012075
- Report Number(s):
- CONF-851065-1; ON: DE86002201
- Resource Relation:
- Conference: Workshop on radiation damage to skin: fundamental and practical aspects, Paris, France, 9 Oct 1985
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CARCINOMAS
RADIOINDUCTION
FIBROSARCOMAS
ULTRAVIOLET RADIATION
CARCINOGENESIS
X RADIATION
CESIUM 137
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
FRACTIONATED IRRADIATION
GAMMA RADIATION
MICE
PHORBOL ESTERS
SKIN
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARCINOGENS
CESIUM ISOTOPES
DATA
DISEASES
ELECTROMAGNETIC RADIATION
ESTERS
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MAMMALS
NEOPLASMS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
RADIATIONS
RADIOISOTOPES
RODENTS
SARCOMAS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals