Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor

Holden, N E; Rorer, D C; Patti, F J; Liu, H B; Reciniello, R; Chanana, A D

Title: Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor

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Abstract

The Brookhaven Medical Research Reactor, BMRR, is a 3 MW heterogeneous, tank-type, light water cooled and moderated, graphite reflected reactor, which was designed for biomedical studies. Early BNL work in Boron Neutron Capture Therapy (BNCT) used a beam of thermal neutrons for experimental treatment of brain tumors. Research elsewhere and at BNL indicated that higher energy neutrons would be required to treat deep seated brain tumors. Epithermal neutrons would be thermalized as they penetrated the brain and peak thermal neutron flux densities would occur at the depth of brain tumors. One of the two BMRR thermal port shutters was modified in 1988 to include plates of aluminum and aluminum oxide to provide an epithermal port. Lithium carbonate in polyethylene was added in 1991 around the bismuth port to reduce the neutron flux density coming from outside the port. To enhance the epithermal neutron flux density, the two vertical thimbles A-3 (core edge) and E-3 (in core) were replaced with fuel elements. There are now four fuel elements of 190 grams each and 28 fuel elements of 140 grams each for a total of 4.68 kg of {sup 235}U in the core. The authors have proposed replacing the epithermal shutter withmore »« less

Authors:: Holden, N E; Rorer, D C; Patti, F J; Liu, H B; Reciniello, R; Chanana, A D

Publication Date:: Tue Jul 01 00:00:00 EDT 1997

Research Org.:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE Office of Energy Research, Washington, DC (United States)

OSTI Identifier:: 495766

Report Number(s):: BNL-64441; CONF-970524-2
ON: DE97006753; TRN: 97:013200

DOE Contract Number:: AC02-76CH00016

Resource Type:: Conference

Resource Relation:: Conference: International conference on nuclear data for science and technology, Trieste (Italy), 19-24 May 1997; Other Information: PBD: [1997]

Country of Publication:: United States

Language:: English

Subject:: 55 BIOLOGY AND MEDICINE, BASIC STUDIES; 22 NUCLEAR REACTOR TECHNOLOGY; MRR REACTOR; NEUTRON CAPTURE THERAPY; MODIFICATIONS; NEOPLASMS; BORON 10; PERSONNEL DOSIMETRY; BRAIN; NEUTRON FLUX; FLUX DENSITY; REACTION PRODUCT TRANSPORT SYSTEMS; EPITHERMAL NEUTRONS

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                    Holden, N E, Rorer, D C, Patti, F J, Liu, H B, Reciniello, R, and Chanana, A D. Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor.  United States: N. p., 1997. 
        Web.

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                    Holden, N E, Rorer, D C, Patti, F J, Liu, H B, Reciniello, R, & Chanana, A D. Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor.  United States.

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                    Holden, N E, Rorer, D C, Patti, F J, Liu, H B, Reciniello, R, and Chanana, A D. 1997.  
        "Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor".  United States.  https://www.osti.gov/servlets/purl/495766.

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@article{osti_495766,

  title        = {Technical aspects of boron neutron capture therapy at the BNL Medical Research Reactor},

  author       = {Holden, N E and Rorer, D C and Patti, F J and Liu, H B and Reciniello, R and Chanana, A D},

  abstractNote = {The Brookhaven Medical Research Reactor, BMRR, is a 3 MW heterogeneous, tank-type, light water cooled and moderated, graphite reflected reactor, which was designed for biomedical studies. Early BNL work in Boron Neutron Capture Therapy (BNCT) used a beam of thermal neutrons for experimental treatment of brain tumors. Research elsewhere and at BNL indicated that higher energy neutrons would be required to treat deep seated brain tumors. Epithermal neutrons would be thermalized as they penetrated the brain and peak thermal neutron flux densities would occur at the depth of brain tumors. One of the two BMRR thermal port shutters was modified in 1988 to include plates of aluminum and aluminum oxide to provide an epithermal port. Lithium carbonate in polyethylene was added in 1991 around the bismuth port to reduce the neutron flux density coming from outside the port. To enhance the epithermal neutron flux density, the two vertical thimbles A-3 (core edge) and E-3 (in core) were replaced with fuel elements. There are now four fuel elements of 190 grams each and 28 fuel elements of 140 grams each for a total of 4.68 kg of {sup 235}U in the core. The authors have proposed replacing the epithermal shutter with a fission converter plate shutter. It is estimated that the new shutter would increase the epithermal neutron flux density by a factor of seven and the epithermal/fast neutron ratio by a factor of two. The modifications made to the BMRR in the past few years permit BNCT for brain tumors without the need to reflect scalp and bone flaps. Radiation workers are monitored via a TLD badge and a self-reading dosimeter during each experiment. An early concern was raised about whether workers would be subject to a significant dose rate from working with patients who have been irradiated. The gamma ray doses for the representative key personnel involved in the care of the first 12 patients receiving BNCT are listed. These workers did not receive unusually high exposures.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/495766},
  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Jul 01 00:00:00 EDT 1997},

  month        = {Tue Jul 01 00:00:00 EDT 1997}

}

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