HIV transcription is induced with some forms of cell killing
- Argonne National Lab., IL (United States)
- Argonne National Lab., IL (United States); South Carolina Univ., Columbia, SC (United States). Dept. of Chemistry
- Loyola Univ. Medical Center, Maywood, IL (United States)
Using HeLa cells stably transfected with an HIV-LTR-CAT construct`, we demonstrated a peak in CAT induction that occurs in viable (but not necessarily cell-division-competent) cells 24 h following exposure to some cell-killing agents. {Gamma} rays were the only cell-killing agent which did not induce HIV transcription; this can be attributed to the fact that {gamma}-ray-induced apoptotic death requires function p53, which is missing in HeLa cells. For all other agents, HIV-LTR induction was dose-dependent and correlated with the amount of cell killing that occurred in the culture.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE Office of Energy Research, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 405748
- Report Number(s):
- ANL/CMB/PP-83769; ON: DE97001021; TRN: 97:001195
- Resource Relation:
- Other Information: PBD: [1996]
- Country of Publication:
- United States
- Language:
- English
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