Bone sarcoma in humans induced by radium: A threshold response?
The radium 226 and radium 228 have induced malignancies in the skeleton (primarily bone sarcomas) of humans. They have also induced carcinomas in the paranasal sinuses and mastoid air cells. There is no evidence that any leukemias or any other solid cancers have been induced by internally deposited radium. This paper discuses a study conducted on the dial painter population. This study made a concerted effort to verify, for each of the measured radium cases, the published values of the skeletal dose and the initial intake of radium. These were derived from body content measurements made some 40 years after the radium intake. Corrections to the assumed radium retention function resulted in a considerable number of dose changes. These changes have changed the shape of the dose response function. It now appears that the induction of bone sarcomas is a threshold process.
- Research Organization:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States)
- DOE Contract Number:
- W-31109-ENG-38
- OSTI ID:
- 371427
- Report Number(s):
- ANL/ER/CP-90343; CONF-9609230-1; ON: DE96013598; TRN: 96:023316
- Resource Relation:
- Conference: 27. annual meeting of the European Society for Radiation Biology, Montpellier (France), 2-4 Sep 1996; Other Information: PBD: [1996]
- Country of Publication:
- United States
- Language:
- English
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