Development of a Structure for Lossless Ion Manipulations (SLIM) High Charge Capacity Array of Traps

Huntley, Adam P.; Hollerbach, Adam L.; Amma, Aneesh Prabhakaran Nair Syamala; Garimella, Sandilya V. B.; Giberson, Cameron M.; Norheim, Randolph V.; Smith, Richard D.; Ibrahim, Yehia M.

doi:10.1021/acs.analchem.2c05025

Title: Development of a Structure for Lossless Ion Manipulations (SLIM) High Charge Capacity Array of Traps

Journal Article · Thu Feb 23 00:00:00 EST 2023 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.2c05025· OSTI ID:1963878

^[1]; Hollerbach, Adam L. ^[1]; Amma, Aneesh Prabhakaran Nair Syamala ^[1];

^[1]; Giberson, Cameron M. ^[1]; Norheim, Randolph V. ^[1];

^[1];

^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Enhancing the sensitivity of low abundance ions in a complex mixture without sacrificing experiment throughput is highly desirable. This work demonstrates a way to greatly improve the sensitivity of ion mobility (IM) selected ions by accumulating them in an array of high-capacity ion traps located inside a novel structures for lossless ion manipulations ion mobility spectrometer (SLIM-IMS) module. The array of ion traps used in this work consisted of seven independently controllable traps. Each trap was 386 mm long and possessed a charge capacity of ~4.5×10⁸ charges, with a linear range extending to ~2.5×10⁸ charges. Each ion trap could be used to extract a peak (or ions over a mobility range) from an ion mobility separation based on arrival time. Ions could be stored without losses for long times (>100 s) and then released all at once or one trap at a time. It was possible to accumulate large ion populations by extracting and storing ions over repeated IM separations. We report enrichment of up to seven individual ion distributions could be performed using the seven independently controllable ion traps. Additionally, the ion trapping process effectively compressed ion populations into narrow peaks, which provides a greatly improved basis for subsequent ion manipulations. The array of high charge-capacity ion traps provides a flexible addition to SLIM and a powerful tool for IMS-MS applications requiring high sensitivity.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: National Institutes of Health (NIH); National Cancer Institute (NCI); National Institute of General Medical Sciences (NIGMS); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1963878

Report Number(s):: PNNL-SA-179607

Journal Information:: Analytical Chemistry, Vol. 95, Issue 9; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
high resolution
ion mobility spectrometry
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traveling waves

Title: Development of a Structure for Lossless Ion Manipulations (SLIM) High Charge Capacity Array of Traps

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