Production and monitoring of metabolites in cells

Rogers, Jameson K.; Church, George M.

Title: Production and monitoring of metabolites in cells

Patent · Tue Jun 21 00:00:00 EDT 2022

OSTI ID:1893055

Rogers, Jameson K.; Church, George M.

Methods of making and monitoring metabolites in cells are provided.

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Research Organization:: Harvard Univ., Cambridge, MA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-02ER63445

Assignee:: President and Fellows of Harvard College (Cambridge, MA)

Patent Number(s):: 11,365,410

Application Number:: 15/566,040

OSTI ID:: 1893055

Resource Relation:: Patent File Date: 04/12/2016

Country of Publication:: United States

Language:: English

References (17)

Whole cell biosensing via recA::mCherry and LED-based flow-through fluorometry Martineau, R. L.; Stout, V.; Towe, B. C. Biosensors and Bioelectronics, Vol. 25, Issue 4 https://doi.org/10.1016/j.bios.2009.08.042	journal	December 2009
Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains Rathnasingh, Chelladurai; Raj, Subramanian Mohan; Lee, Youjin Journal of Biotechnology, Vol. 157, Issue 4, p. 633-640 https://doi.org/10.1016/j.jbiotec.2011.06.008	journal	February 2012
Biosensor-based engineering of biosynthetic pathways Rogers, Jameson K.; Taylor, Noah D.; Church, George M. Current Opinion in Biotechnology, Vol. 42 https://doi.org/10.1016/j.copbio.2016.03.005	journal	December 2016
Selection of biocatalysts for chemical synthesis van Sint Fiet, S.; van Beilen, J. B.; Witholt, B. Proceedings of the National Academy of Sciences, Vol. 103, Issue 6 https://doi.org/10.1073/pnas.0504733102	journal	January 2006
Unusual Regulation of a Leaderless Operon Involved in the Catabolism of Dimethylsulfoniopropionate in Rhodobacter sphaeroides Sullivan, Matthew J.; Curson, Andrew R. J.; Shearer, Neil PLoS ONE, Vol. 6, Issue 1 https://doi.org/10.1371/journal.pone.0015972	journal	January 2011
Genetically encoded sensors enable real-time observation of metabolite production Rogers, Jameson K.; Church, George M. Proceedings of the National Academy of Sciences, Vol. 113, Issue 9 https://doi.org/10.1073/pnas.1600375113	journal	February 2016
Biosensor-guided screening for macrolides Möhrle, V.; Stadler, M.; Eberz, G. Analytical and Bioanalytical Chemistry, Vol. 388, Issue 5-6 https://doi.org/10.1007/s00216-007-1300-5	journal	May 2007
Multiplexed Engineering in Biology Rogers, Jameson K.; Church, George M. Trends in Biotechnology, Vol. 34, Issue 3 https://doi.org/10.1016/j.tibtech.2015.12.004	journal	March 2016
Linker Regions of the RhaS and RhaR Proteins Kolin, Ana; Jevtic, Visnja; Swint-Kruse, Liskin Journal of Bacteriology, Vol. 189, Issue 1 https://doi.org/10.1128/JB.01456-06	journal	January 2007
Sensors For The Detection Of Intracellular Metabolites Eggeling, Lothar; Bott, Michael; Binder, Stephan https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20130310458 US Patent Application 13/695769; 20130310458 A1	patent-application	November 2013
Synthetic biosensors for precise gene control and real-time monitoring of metabolites Rogers, Jameson K.; Guzman, Christopher D.; Taylor, Noah D. Nucleic Acids Research, Vol. 43, Issue 15 https://doi.org/10.1093/nar/gkv616	journal	July 2015
Synthetic RNA devices to expedite the evolution of metabolite-producing microbes Yang, Jina; Seo, Sang Woo; Jang, Sungho Nature Communications, Vol. 4, Issue 1 https://doi.org/10.1038/ncomms2404	journal	January 2013
2-Methylcitrate-dependent activation of the propionate catabolic operon (prpBCDE) of Salmonella enterica by the PrpR protein Palacios, Sergio; Escalante-Semerena, Jorge C. Microbiology, Vol. 150, Issue 11 https://doi.org/10.1099/mic.0.27299-0	journal	November 2004
Evolution-guided optimization of biosynthetic pathways Raman, Srivatsan; Rogers, Jameson K.; Taylor, Noah D. Proceedings of the National Academy of Sciences, Vol. 111, Issue 50, p. 17803-17808 https://doi.org/10.1073/pnas.1409523111	journal	December 2014
Design and Application of a Mevalonate-Responsive Regulatory Protein Tang, Shuang-Yan; Cirino, Patrick C. Angewandte Chemie International Edition, Vol. 50, Issue 5 https://doi.org/10.1002/anie.201006083	journal	December 2010
Direct Biocatalytic Production of Acrylic Acid and Other Carboxylic Acid Compounds Valle, Fernando; Agard, Nicholas John; Noriega, Christopher https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20140342414 US Patent Application 14/345495; 20140342414 A1	patent-application	November 2014
Engineering an allosteric transcription factor to respond to new ligands Taylor, Noah D.; Garruss, Alexander S.; Moretti, Rocco Nature Methods, Vol. 13, Issue 2 https://doi.org/10.1038/nmeth.3696	journal	December 2015

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