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Title: Protein and nucleic acid detection for microfluidic devices

Patent ·
OSTI ID:1823861
;

The present invention relates to methods for detecting targets by employing a temperature control system with a microfluidic device. The system allows for non-contact heating by employing an infrared emitter. In some instances, the system can be used in conjunction with a centrifugal microfluidic device. Optionally, a mask can be implemented to provide selective heating of desired assay areas of the device.

Research Organization:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Organization:
USDOE National Nuclear Security Administration (NNSA); National Institutes of Health (NIH)
DOE Contract Number:
NA0003525; R01AI098853
Assignee:
National Technology & Engineering Solutions of Sandia, LLC (Albuquerque, NM)
Patent Number(s):
10,981,174
Application Number:
16/399,484
OSTI ID:
1823861
Resource Relation:
Patent File Date: 04/30/2019
Country of Publication:
United States
Language:
English

References (76)

Microparticle-based methods and systems and applications thereof patent-application December 2005
Integrated planar microfluidic bioanalytical systems patent-application August 2006
Method for Separating Cells patent-application May 2008
Diagnostic tests and kits for Clostridium difficile patent January 2003
Systems, Devices, and Methods For Agglutination Assays Using Sedimentation patent-application March 2016
Method and apparatus for purifying nucleic acids and performing polymerase chain reaction assays using an immiscible fluid patent-application February 2018
Method and apparatus for measuring blood constituent counts patent July 1987
DNA purification and isolation using magnetic particles patent January 1998
Method for retrieving delta9-THC from oral fluid patent-application April 2006
Method and Apparatus For Precise Transfer and Manipulation Of Fluids By Centrifugal and Or Capillary Forces patent-application January 2009
Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto patent January 2007
Class characterization of circulating cancer cells isolated from body fluids and methods of use patent-application July 2002
Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species patent-application October 2003
Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay patent June 1997
Centrifugal force based microfluidic device, microfluidic system including the same, and method of determining home position of the microfluidic device patent July 2010
Toxin Activity Assays, Devices, Methods And Systems Therefor patent-application June 2016
System and method for detecting components of a mixture including a valving scheme for competition assays patent July 2017
Multichannel control in microfluidics patent-application October 2002
Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent February 2015
Multistation, Single Channel Analytical Photometer and Method of Use patent January 1971
Analytical methods and compositions patent-application November 2002
Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids patent February 2008
Multi-parameter assays including analysis discs and methods relating thereto patent-application October 2002
Microfluidic devices and methods patent-application January 2003
Microfluidic Devices, Systems, And Methods For Quantifying Particles Using Centrifugal Force patent-application December 2015
Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent November 2001
Diagnostic Analyzers With Pretreatment Carousels and Related Methods patent-application September 2014
System and method for detecting components of a mixture including tooth elements for alignment patent November 2016
Separation of solid and liquid components of mixtures patent November 1978
Devices, systems, and methods for conducting sandwich assays using sedimentation patent February 2015
Microfluidic devices, systems, and methods for quantifying particles using centrifugal force patent November 2015
Apparatus and method for measuring white blood cell and platelet concentrations in blood patent May 1979
Antibody and immunoassays for determining the presence of Δ9-Tetrahydrocannabinol patent July 2010
Microfluidic particle-analysis systems patent-application April 2004
Novel multi-analyte optical computing system patent-application December 2010
System and method for detecting components of a mixture including a valving scheme for competition assays patent September 2017
Loading Disk for Photometric Analyzer of Rotary Cuvette Type patent July 1973
Multi-parameter assays including analysis discs and methods relating thereto patent April 2006
Separation Device patent-application May 2010
Centrifugation Apparatus For Containers Of Biological Material patent-application February 2011
Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces patent December 2012
Thermoelectric sensor for analytes in a gas and related method patent-application March 2008
Method for separating the cellular components of blood samples patent July 1989
Immunoassay for tetrahydrocannabinol metabolites patent May 1989
Reagents for labeling biomolecules having aldehyde or ketone Moieties patent-application September 2002
Microporation of tissue for delivery of bioactive agents patent-application April 2003
Plastic microfluidics enabling two-dimensional protein separations in proteome analysis patent-application November 2002
Density-based cell detection system patent March 2010
Devices, systems, and methods for detecting nucleic acids using sedimentation patent-application March 2018
Protecting agent patent-application August 2005
Methods for fragmenting DNA patent-application September 2005
Apparatus and method for carrying out analysis of samples patent April 1999
Class characterization of circulating cancer cells isolated from body fluids and methods of use patent November 2005
Systems, devices, and methods for agglutination assays using sedimentation patent January 2016
Assay of blood or other biologic samples for target analytes patent June 1997
Method for detecting analytes in a sample patent-application December 2009
Delta-9-tetrahydrocannabinol detection method patent September 2010
Toxin activity assays, devices, methods and systems therefor patent April 2016
Centrifuge with removable core for scalable centrifugation patent-application September 2005
Centrifugal hematology disposable patent November 2000
Microfluidics devices and methods for performing cell based assays patent-application August 2002
Microfluidic particle-analysis systems patent December 2007
Centrifugal Separation System patent-application August 2009
Heterogeneous binding assay patent April 1987
Monolithic microfluidic concentrators and mixers patent May 2005
Compact disk based platform for separating and detecting immunomagnetic bead labeled cells patent-application June 2010
Devices and Method For Using Centripetal Acceleration To Drive Fluid Movement In A Microfluidics System With On-Board Informatics patent-application December 2001
Method of separation employing magnetic particles and second medium patent January 1994
Systems and Methods for Handling Microfluidic Droplets patent-application October 2013
Assay system and method for conducting assays patent March 1999
Devices, systems, and methods for conducting assays with improved sensitivity using sedimentation patent April 2016
Method Of Detecting Analyte-Molecule Interactions patent-application June 2008
Method For Isolating Nucleic Acids Comprising The Use Of Ethylene Glycol Multimers patent-application March 2009
Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device patent November 1985
Method for separating cells patent-application July 2003
Quantitative detection of pathogens in centrifugal microfluidic disks patent-application February 2018

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