Lipid biosynthesis and abiotic stress resilience in photosynthetic organisms

Bonito, Gregory; Du, Zhi-Yan; Benning, Christoph

Title: Lipid biosynthesis and abiotic stress resilience in photosynthetic organisms

Patent · Tue Dec 08 00:00:00 EST 2020

OSTI ID:1771706

Bonito, Gregory; Du, Zhi-Yan; Benning, Christoph

This application describes consortium between fungi and algae, where the algae are incorporated within hyphae of the fungi. The fungi, the algae, or both can be modified to express heterologous lipid synthesizing enzymes. Incorporation of algae into fungi facilitates harvesting of the algae and products produced by the consortia. Such consortia are robust. For example, the fungi and algae can symbiotically provide nutrients to each other and are tolerant of environmental stresses.

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Research Organization:: Michigan State Univ., East Lansing, MI (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FC02-07ER64494; FG02-91ER20021; SC0018409

Assignee:: Board of Trustees of Michigan State University (East Lansing, MI)

Patent Number(s):: 10,858,687

Application Number:: 16/058,632

OSTI ID:: 1771706

Resource Relation:: Patent File Date: 08/08/2018

Country of Publication:: United States

Language:: English

References (36)

Algae's Second Try Service, R. F. Science, Vol. 333, Issue 6047 https://doi.org/10.1126/science.333.6047.1238	journal	September 2011
Functional analysis of liverworts in dual symbiosis with Glomeromycota and Mucoromycotina fungi under a simulated Palaeozoic CO2 decline Field, Katie J.; Rimington, William R.; Bidartondo, Martin I. The ISME Journal, Vol. 10, Issue 6 https://doi.org/10.1038/ismej.2015.204	journal	November 2015
A Secondary Symbiosis in Progress? Okamoto, Noriko; Inouye, Isao Science, Vol. 310, Issue 5746 https://doi.org/10.1126/science.1116125	journal	October 2005
Assaying chimeric genes in plants: The GUS gene fusion system Jefferson, Richard A. Plant Molecular Biology Reporter, Vol. 5, Issue 4 https://doi.org/10.1007/BF02667740	journal	December 1987
Regulatory Factors Controlling Oil Biosynthesis in Microalgae and Their Use Benning, Christoph; Miller, Rachel; Moellering, Eric R. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100255550 US Patent Application 12/559974; 20100255550	patent-application	October 2010
Mechanisms underlying beneficial plant–fungus interactions in mycorrhizal symbiosis Bonfante, Paola; Genre, Andrea Nature Communications, Vol. 1, Issue 1 https://doi.org/10.1038/ncomms1046	journal	July 2010
Method of inducing lysine overproduction in plants Glassman, Kimberly F.; Barnes, Linda J.; Pilacinski, William P. https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5258300 US Patent Document 5,258,300	patent	November 1993
Niche engineering demonstrates a latent capacity for fungal-algal mutualism Hom, Erik F. Y.; Murray, Andrew W. Science, Vol. 345, Issue 6192 https://doi.org/10.1126/science.1253320	journal	July 2014
A phylum-level phylogenetic classification of zygomycete fungi based on genome-scale data Spatafora, Joseph W.; Chang, Ying; Benny, Gerald L. Mycologia, Vol. 108, Issue 5 https://doi.org/10.3852/16-042	journal	September 2016
A simple procedure for dissolving fungal cell wall preparations for the analysis of neutral sugars Velichkov, A. D. World Journal of Microbiology & Biotechnology, Vol. 8, Issue 5 https://doi.org/10.1007/BF01201953	journal	September 1992
CONDITIONAL PRODUCTION OF A FUNCTIONAL FISH GROWTH HORMONE IN THE TRANSGENIC LINE OF NANNOCHLOROPSIS OCULATA (EUSTIGMATOPHYCEAE) Chen, Hsin Liang; Li, Si Shen; Huang, Rang Journal of Phycology, Vol. 44, Issue 3 https://doi.org/10.1111/j.1529-8817.2008.00508.x	journal	June 2008
Origin of land plants: Do conjugating green algae hold the key? Wodniok, Sabina; Brinkmann, Henner; Glöckner, Gernot BMC Evolutionary Biology, Vol. 11, Issue 1 https://doi.org/10.1186/1471-2148-11-104	journal	April 2011
Studies on initiation and development of the partner association inGeosiphon pyriforme (K�tz.) v. Wettstein, a unique endocytobiotic system of a fungus (Glomales) and the cyanobacteriumNostoc punctiforme (K�tz.) Hariot Mollenhauer, D.; Mollenhauer, R.; Kluge, M. Protoplasma, Vol. 193, Issue 1-4 https://doi.org/10.1007/BF01276630	journal	March 1996
Transcriptional coordination of physiological responses in Nannochloropsis oceanica CCMP1779 under light/dark cycles Poliner, Eric; Panchy, Nicholas; Newton, Linsey The Plant Journal, Vol. 83, Issue 6 https://doi.org/10.1111/tpj.12944	journal	August 2015
Binary Agrobacterium vectors for plant transformation Bevan, Michael Nucleic Acids Research, Vol. 12, Issue 22 https://doi.org/10.1093/nar/12.22.8711	journal	January 1984
Lipid Biosynthesis and Abiotic Stress Resilience in Hotosynthetic Organisms Bonito, Gregory; Du, Zhi-Yan; Benning, Christoph https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20180230420 US Patent Application 15/894457; 20180230420	patent-application	August 2018
Exploiting diversity and synthetic biology for the production of algal biofuels Georgianna, D. Ryan; Mayfield, Stephen P. Nature, Vol. 488, Issue 7411 https://doi.org/10.1038/nature11479	journal	August 2012
Microcolonial rock inhabiting fungi and lichen photobionts: evidence for mutualistic interactions Gorbushina, Anna A.; Beck, Andreas; Schulte, Anette Mycological Research, Vol. 109, Issue 11 https://doi.org/10.1017/S0953756205003631	journal	November 2005
The bialaphos biosynthetic genes ofStreptomyces hygroscopicus: Molecular cloning and characterization of the gene cluster Murakami, Takeshi; Anzai, Hiroyuki; Imai, Satoshi Molecular and General Genetics MGG, Vol. 205, Issue 1 https://doi.org/10.1007/BF02428031	journal	October 1986
Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim. Thillet, J.; Absil, J.; Stone, S. R. Journal of Biological Chemistry, Vol. 263, Issue 25 https://doi.org/10.1016/S0021-9258(18)37783-4	journal	September 1988
Delivery Systems for Mycotechnologies, Mycofiltration and Mycoremediation Statmets, Paul Edward https://doi.org/https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080264858 US Patent Application 12/214934; 20080264858	patent-application	October 2008
Genome, Functional Gene Annotation, and Nuclear Transformation of the Heterokont Oleaginous Alga Nannochloropsis oceanica CCMP1779 Vieler, Astrid; Wu, Guangxi; Tsai, Chia-Hong PLoS Genetics, Vol. 8, Issue 11 https://doi.org/10.1371/journal.pgen.1003064	journal	November 2012
Isolating a functionally relevant guild of fungi from the root microbiome of Populus Bonito, Gregory; Hameed, Khalid; Ventura, Rafael Fungal Ecology, Vol. 22 https://doi.org/10.1016/j.funeco.2016.04.007	journal	August 2016
Algal ancestor of land plants was preadapted for symbiosis Delaux, Pierre-Marc; Radhakrishnan, Guru V.; Jayaraman, Dhileepkumar Proceedings of the National Academy of Sciences, Vol. 112, Issue 43 https://doi.org/10.1073/pnas.1515426112	journal	October 2015
A Gene Cluster Encoding Rhizoxin Biosynthesis in “Burkholderia rhizoxina”, the Bacterial Endosymbiont of the FungusRhizopus microsporus Partida-Martinez, Laila P.; Hertweck, Christian ChemBioChem, Vol. 8, Issue 1 https://doi.org/10.1002/cbic.200600393	journal	January 2007
Ultrastructure and Composition of the Nannochloropsis gaditana Cell Wall Scholz, Matthew J.; Weiss, Taylor L.; Jinkerson, Robert E. Eukaryotic Cell, Vol. 13, Issue 11 https://doi.org/10.1128/EC.00183-14	journal	September 2014
Glomalean Fungi from the Ordovician Redecker, D. Science, Vol. 289, Issue 5486 https://doi.org/10.1126/science.289.5486.1920	journal	September 2000
Nannochloropsis, a rich source of diacylglycerol acyltransferases for engineering of triacylglycerol content in different hosts Zienkiewicz, Krzysztof; Zienkiewicz, Agnieszka; Poliner, Eric Biotechnology for Biofuels, Vol. 10, Issue 1 https://doi.org/10.1186/s13068-016-0686-8	journal	January 2017
Flexibility in Algal Endosymbioses Shapes Growth in Reef Corals Little, A. F. Science, Vol. 304, Issue 5676 https://doi.org/10.1126/science.1095733	journal	June 2004
Self-supporting artificial system of the green alga Chlamydomonas reinhardtii and the ascomycetous fungus Alternaria infectoria Simon, Janka; Kósa, Annamária; Bóka, Károly Symbiosis, Vol. 71, Issue 3 https://doi.org/10.1007/s13199-016-0430-y	journal	June 2016
The protein Compromised Hydrolysis of Triacylglycerols 7 (CHT7) acts as a repressor of cellular quiescence in Chlamydomonas Tsai, C. -H.; Warakanont, J.; Takeuchi, T. Proceedings of the National Academy of Sciences, Vol. 111, Issue 44 https://doi.org/10.1073/pnas.1414567111	journal	October 2014
Molecular mechanisms for photosynthetic carbon partitioning into storage neutral lipids in Nannochloropsis oceanica under nitrogen-depletion conditions Jia, Jing; Han, Danxiang; Gerken, Henri G. Algal Research, Vol. 7 https://doi.org/10.1016/j.algal.2014.11.005	journal	January 2015
Are Vascular Plants "Inside-Out" Lichens? Atsatt, Peter R. Ecology, Vol. 69, Issue 1 https://doi.org/10.2307/1943156	journal	February 1988
Artificial Reestablishment of the Lichen Cladonia cristatella Ahmadjian, V. Science, Vol. 151, Issue 3707 https://doi.org/10.1126/science.151.3707.199	journal	January 1966
Engineering microbial consortia: a new frontier in synthetic biology Brenner, Katie; You, Lingchong; Arnold, Frances H. Trends in Biotechnology, Vol. 26, Issue 9, p. 483-489 https://doi.org/10.1016/j.tibtech.2008.05.004	journal	September 2008
Symbiotic options for the conquest of land Field, Katie J.; Pressel, Silvia; Duckett, Jeffrey G. Trends in Ecology & Evolution, Vol. 30, Issue 8 https://doi.org/10.1016/j.tree.2015.05.007	journal	August 2015

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