Dynamically-adaptive live therapeutic agents and methods of use thereof

Yung, Mimi Cho; Coleman, Matthew A.; D'Haeseleer, Patrik; Harris, Howard; Jiao, Yongqin; Overton, Kenneth W.; Park, Dan Mcfarland; Segelke, Brent W.; Wong, Sergio E.

Title: Dynamically-adaptive live therapeutic agents and methods of use thereof

Patent · Tue Oct 20 00:00:00 EDT 2020

OSTI ID:1771529

Yung, Mimi Cho; Coleman, Matthew A.; D'Haeseleer, Patrik; Harris, Howard; Jiao, Yongqin; Overton, Kenneth W.; Park, Dan Mcfarland; Segelke, Brent W.; Wong, Sergio E.

This disclosure provides microbes engineered to detect virulent and spore states of pathogens and release an appropriate therapeutic response accordingly and compositions and methods of use of the same.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC52-07NA27344

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Number(s):: 10,808,232

Application Number:: 15/438,638

OSTI ID:: 1771529

Resource Relation:: Patent File Date: 02/21/2017

Country of Publication:: United States

Language:: English

References (11)

Tuning Response Curves for Synthetic Biology Ang, Jordan; Harris, Edouard; Hussey, Brendan J. ACS Synthetic Biology, Vol. 2, Issue 10 https://doi.org/10.1021/sb4000564	journal	September 2013
Clostridium difficile spore biology: sporulation, germination, and spore structural proteins Paredes-Sabja, Daniel; Shen, Aimee; Sorg, Joseph A. Trends in Microbiology, Vol. 22, Issue 7 https://doi.org/10.1016/j.tim.2014.04.003	journal	July 2014
Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen Awad, Milena M.; Johanesen, Priscilla A.; Carter, Glen P. Gut Microbes, Vol. 5, Issue 5 https://doi.org/10.4161/19490976.2014.969632	journal	September 2014
Clostridium difficile Has Two Parallel and Essential Sec Secretion Systems Fagan, Robert P.; Fairweather, Neil F. Journal of Biological Chemistry, Vol. 286, Issue 31 https://doi.org/10.1074/jbc.M111.263889	journal	June 2011
Functional roles for noise in genetic circuits Eldar, Avigdor; Elowitz, Michael B. Nature, Vol. 467, Issue 7312 https://doi.org/10.1038/nature09326	journal	September 2010
Developing Genetically Engineered Encapsulin Protein Cage Nanoparticles as a Targeted Delivery Nanoplatform Moon, Hyojin; Lee, Jisu; Min, Junseon Biomacromolecules, Vol. 15, Issue 10 https://doi.org/10.1021/bm501066m	journal	September 2014
Genetically Programmable Pathogen Sense and Destroy Gupta, Saurabh; Bram, Eran E.; Weiss, Ron ACS Synthetic Biology, Vol. 2, Issue 12 https://doi.org/10.1021/sb4000417	journal	July 2013
Nontoxigenic Clostridium difficile Protects Hamsters against Challenge with Historic and Epidemic Strains of Toxigenic BI/NAP1/027 C. difficile Nagaro, Kristin J.; Phillips, S. Tyler; Cheknis, Adam K. Antimicrobial Agents and Chemotherapy, Vol. 57, Issue 11 https://doi.org/10.1128/AAC.00580-13	journal	August 2013
Bile Salts and Glycine as Cogerminants for Clostridium difficile Spores Sorg, J. A.; Sonenshein, A. L. Journal of Bacteriology, Vol. 190, Issue 7 https://doi.org/10.1128/JB.01765-07	journal	February 2008
Engineering microbes to sense and eradicate Pseudomonas aeruginosa , a human pathogen Saeidi, Nazanin; Wong, Choon Kit; Lo, Tat‐Ming Molecular Systems Biology, Vol. 7, Issue 1 https://doi.org/10.1038/msb.2011.55	journal	January 2011
Clostridium difficile—A continually evolving and problematic pathogen Dawson, Lisa F.; Valiente, Esmeralda; Wren, Brendan W. Infection, Genetics and Evolution, Vol. 9, Issue 6 https://doi.org/10.1016/j.meegid.2009.06.005	journal	December 2009

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