Studies of the brain cannabinoid system using positron emission tomography
Studies using radiolabeled psychoactive drugs in conjunction with positron emission tomography (PET) have permitted the imaging of binding sites in the human brain. Similar studies of marijuana have been hampered by the unsuitability of radiolabeled THC for PET studies, and the current unavailability of other in vivo imaging agents for cannabinoid receptors. Recent developments in medicinal chemistry suggest that a PET radiotracer for cannabinoid receptors will soon become available. This chapter briefly reviews these developments, together with the results of PET studies of the effects of marijuana and other abused drugs on brain metabolism. It also reviews PET studies of cocaine binding sites, to demonstrate the kind of investigations that will be possible when a cannabinoid receptor PET radioligand becomes available.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States)
- Sponsoring Organization:
- USDOE, Washington, DC (United States); Department of Health and Human Services, Washington, DC (United States)
- DOE Contract Number:
- AC02-76CH00016
- OSTI ID:
- 168378
- Report Number(s):
- BNL-62252; CONF-9509278-1; ON: DE96000891; CNN: Grant 5R01-DA06891; TRN: 96:003064
- Resource Relation:
- Conference: Drug abuse in the decade of the brain, Houston, TX (United States), 22-23 Sep 1995; Other Information: PBD: [1995]
- Country of Publication:
- United States
- Language:
- English
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