Methylxanthine Drug Monitoring with Wearable Sweat Sensors

Tai, Li-Chia; Gao, Wei; Chao, Minghan; Bariya, Mallika; Ngo, Quynh P.; Shahpar, Ziba; Nyein, Hnin Y. Y.; Park, Hyejin; Sun, Junfeng; Jung, Younsu; Wu, Eric; Fahad, Hossain M.; Lien, Der-Hsien; Ota, Hiroki; Cho, Gyoujin; Javey, Ali

doi:10.1002/adma.201707442

Title: Methylxanthine Drug Monitoring with Wearable Sweat Sensors

Journal Article · Mon Apr 16 00:00:00 EDT 2018 · Advanced Materials

DOI:https://doi.org/10.1002/adma.201707442· OSTI ID:1638977

Tai, Li-Chia ^[1];

^[1]; Chao, Minghan ^[1]; Bariya, Mallika ^[1]; Ngo, Quynh P. ^[1]; Shahpar, Ziba ^[1]; Nyein, Hnin Y. Y. ^[1]; Park, Hyejin ^[2]; Sun, Junfeng ^[2]; Jung, Younsu ^[2]; Wu, Eric ^[1]; Fahad, Hossain M. ^[1]; Lien, Der-Hsien ^[1]; Ota, Hiroki ^[1]; Cho, Gyoujin ^[2]; Javey, Ali ^[1]

Univ. of California, Berkeley, CA (United States). Dept. of Electrical Engineering and Computer Sciences and Berkeley Sensor and Actuator Center; Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials Sciences Division
Sunchon National Univ., Suncheon (South Korea). Department of Printed Electronics Engineering

Drug monitoring plays crucial roles in doping control and precision medicine. It helps physicians tailor drug dosage for optimal benefits, track patients' compliance to prescriptions, and understand the complex pharmacokinetics of drugs. Conventional drug tests rely on invasive blood draws. While urine and sweat are attractive alternative biofluids, the state-of-the-art methods require separate sample collection and processing steps and fail to provide real-time information. In this paper, a wearable platform equipped with an electrochemical differential pulse voltammetry sensing module for drug monitoring is presented. A methylxanthine drug, caffeine, is selected to demonstrate the platform's functionalities. Sweat caffeine levels are monitored under various conditions, such as drug doses and measurement time after drug intake. Elevated sweat caffeine levels upon increasing dosage and confirmable caffeine physiological trends are observed. This work leverages a wearable sweat sensing platform toward noninvasive and continuous point-of-care drug monitoring and management.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Materials Sciences & Engineering Division; National Science Foundation (NSF); Ministry of Food and Drug Safety in the Republic of Korea

Grant/Contract Number:: AC02-05CH11231; 16163KKMFDS001

OSTI ID:: 1638977

Alternate ID(s):: OSTI ID: 1433448

Journal Information:: Advanced Materials, Vol. 30, Issue 23; ISSN 0935-9648

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 178 works

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References (49)

Soft Microfluidic Assemblies of Sensors, Circuits, and Radios for the Skin Xu, Sheng; Zhang, Yihui; Jia, Lin Science, Vol. 344, Issue 6179 https://doi.org/10.1126/science.1250169	journal	April 2014
Coffee, tea and caffeine intake and the risk of severe depression in middle-aged Finnish men: the Kuopio Ischaemic Heart Disease Risk Factor Study Ruusunen, Anu; Lehto, Soili M.; Tolmunen, Tommi Public Health Nutrition, Vol. 13, Issue 8 https://doi.org/10.1017/S1368980010000509	journal	April 2010
Screening for drugs of abuse in hair with ion spray LC–MS–MS Kronstrand, Robert; Nyström, Ingrid; Strandberg, Joakim Forensic Science International, Vol. 145, Issue 2-3 https://doi.org/10.1016/j.forsciint.2004.04.034	journal	October 2004
An ultra-lightweight design for imperceptible plastic electronics Kaltenbrunner, Martin; Sekitani, Tsuyoshi; Reeder, Jonathan Nature, Vol. 499, Issue 7459 https://doi.org/10.1038/nature12314	journal	July 2013
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis Gao, Wei; Emaminejad, Sam; Nyein, Hnin Yin Yin Nature, Vol. 529, Issue 7587 https://doi.org/10.1038/nature16521	journal	January 2016
Caffeine renal clearance and urine caffeine concentrations during steady state dosing. Implications for monitoring caffeine intake during sports events. Birkett, Dj; Miners, Jo British Journal of Clinical Pharmacology, Vol. 31, Issue 4 https://doi.org/10.1111/j.1365-2125.1991.tb05553.x	journal	April 1991
Urine Drug Testing of Chronic Pain Patients: Licit and Illicit Drug Patterns Cone, E. J.; Caplan, Y. H.; Black, D. L. Journal of Analytical Toxicology, Vol. 32, Issue 8 https://doi.org/10.1093/jat/32.8.530	journal	October 2008
Exercise endurance 1, 3, and 6 h after caffeine ingestion in caffeine users and nonusers Bell, Douglas G.; McLellan, Tom M. Journal of Applied Physiology, Vol. 93, Issue 4 https://doi.org/10.1152/japplphysiol.00187.2002	journal	October 2002
Validation of the Direct Analysis in Real Time Source for Use in Forensic Drug Screening Steiner, Robert R.; Larson, Robyn L. Journal of Forensic Sciences, Vol. 54, Issue 3 https://doi.org/10.1111/j.1556-4029.2009.01006.x	journal	May 2009
Bio-sensing textile based patch with integrated optical detection system for sweat monitoring Morris, Deirdre; Coyle, Shirley; Wu, Yanzhe Sensors and Actuators B: Chemical, Vol. 139, Issue 1 https://doi.org/10.1016/j.snb.2009.02.032	journal	May 2009
Effect of caffeinated drinks on substrate metabolism, caffeine excretion, and performance Kovacs, Eva M. R.; Stegen, Jos H. C. H.; Brouns, Fred Journal of Applied Physiology, Vol. 85, Issue 2 https://doi.org/10.1152/jappl.1998.85.2.709	journal	August 1998
Metabolic, catecholamine, and exercise performance responses to various doses of caffeine Graham, T. E.; Spriet, L. L. Journal of Applied Physiology, Vol. 78, Issue 3 https://doi.org/10.1152/jappl.1995.78.3.867	journal	March 1995
Voltammetric studies on the HIV-1 inhibitory drug Efavirenz: The interaction between dsDNA and drug using electrochemical DNA biosensor and adsorptive stripping voltammetric determination on disposable pencil graphite electrode Dogan-Topal, Burcu; Uslu, Bengi; Ozkan, Sibel A. Biosensors and Bioelectronics, Vol. 24, Issue 8 https://doi.org/10.1016/j.bios.2008.12.005	journal	April 2009
Spheroid-based drug screen: considerations and practical approach Friedrich, Juergen; Seidel, Claudia; Ebner, Reinhard Nature Protocols, Vol. 4, Issue 3 https://doi.org/10.1038/nprot.2008.226	journal	February 2009
Caffeine and Performance Spriet, Lawrence L. International Journal of Sport Nutrition, Vol. 5, Issue s1 https://doi.org/10.1123/ijsn.5.s1.s84	journal	June 1995
Human Saliva as a Diagnostic Specimen Hofman, Lindsay F. The Journal of Nutrition, Vol. 131, Issue 5 https://doi.org/10.1093/jn/131.5.1621S	journal	May 2001
Dendrimer modified graphite sensors for detection of anticancer drug Daunorubicin by voltammetry and electrochemical impedance spectroscopy Erdem, Arzum; Karadeniz, Hakan; Caliskan, Ayfer The Analyst, Vol. 136, Issue 5 https://doi.org/10.1039/c0an00357c	journal	January 2011
A wearable chemical–electrophysiological hybrid biosensing system for real-time health and fitness monitoring Imani, Somayeh; Bandodkar, Amay J.; Mohan, A. M. Vinu Nature Communications, Vol. 7, Issue 1 https://doi.org/10.1038/ncomms11650	journal	May 2016
Nanowire active-matrix circuitry for low-voltage macroscale artificial skin Takei, Kuniharu; Takahashi, Toshitake; Ho, Johnny C. Nature Materials, Vol. 9, Issue 10, p. 821-826 https://doi.org/10.1038/nmat2835	journal	September 2010
The Erythromycin Breath Test For the Prediction of Drug Clearance Rivory, Laurent P.; Slaviero, Kellie A.; Hoskins, Janelle M. Clinical Pharmacokinetics, Vol. 40, Issue 3 https://doi.org/10.2165/00003088-200140030-00001	journal	January 2001
Drug Excretion in Human Eccrine Sweat Johnson, Howard L.; Maibach, Howard I. Journal of Investigative Dermatology, Vol. 56, Issue 3 https://doi.org/10.1111/1523-1747.ep12260784	journal	March 1971
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy Lee, Hyunjae; Choi, Tae Kyu; Lee, Young Bum Nature Nanotechnology, Vol. 11, Issue 6 https://doi.org/10.1038/nnano.2016.38	journal	March 2016
Monitoring Opiate Use in Substance Abuse Treatment Patients With Sweat and Urine Drug Testing Huestis, M. A.; Cone, E. J.; Wong, C. J. Journal of Analytical Toxicology, Vol. 24, Issue 7 https://doi.org/10.1093/jat/24.7.509	journal	October 2000
Blood pressure response to chronic intake of coffee and caffeine: a meta-analysis of randomized controlled trials Noordzij, Marlies; Uiterwaal, Cuno SPM; Arends, Lidia R. Journal of Hypertension, Vol. 23, Issue 5 https://doi.org/10.1097/01.hjh.0000166828.94699.1d	journal	January 2005
User-interactive electronic skin for instantaneous pressure visualization Wang, Chuan; Hwang, David; Yu, Zhibin Nature Materials, Vol. 12, Issue 10, p. 899-904 https://doi.org/10.1038/nmat3711	journal	July 2013
Highly ordered nanowire arrays on plastic substrates for ultrasensitive flexible chemical sensors McAlpine, Michael C.; Ahmad, Habib; Wang, Dunwei Nature Materials, Vol. 6, Issue 5 https://doi.org/10.1038/nmat1891	journal	April 2007
Sweat Testing in Opioid Users with a Sweat Patch Kintz, P.; Tracqui, A.; Mangin, P. Journal of Analytical Toxicology, Vol. 20, Issue 6 https://doi.org/10.1093/jat/20.6.393	journal	October 1996
Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes Lipomi, Darren J.; Vosgueritchian, Michael; Tee, Benjamin C-K. Nature Nanotechnology, Vol. 6, Issue 12, p. 788-792 https://doi.org/10.1038/nnano.2011.184	journal	October 2011
Ethnic Disparities in Unmet Need for Alcoholism, Drug Abuse, and Mental Health Care Wells, Kenneth; Klap, Ruth; Koike, Alan American Journal of Psychiatry, Vol. 158, Issue 12 https://doi.org/10.1176/appi.ajp.158.12.2027	journal	December 2001
Cardiovascular effects of caffeine in men and women Hartley, Terry R.; Lovallo, William R.; Whitsett, Thomas L. The American Journal of Cardiology, Vol. 93, Issue 8 https://doi.org/10.1016/j.amjcard.2003.12.057	journal	April 2004
Caffeine Content of Specialty Coffees McCusker, R. R.; Goldberger, B. A.; Cone, E. J. Journal of Analytical Toxicology, Vol. 27, Issue 7 https://doi.org/10.1093/jat/27.7.520	journal	October 2003
Epidermal Electronics Kim, D.-H.; Lu, N.; Ma, R. Science, Vol. 333, Issue 6044, p. 838-843 https://doi.org/10.1126/science.1206157	journal	August 2011
A fully roll-to-roll gravure-printed carbon nanotube-based active matrix for multi-touch sensors Lee, Wookyu; Koo, Hyunmo; Sun, Junfeng Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep17707	journal	December 2015
A soft, wearable microfluidic device for the capture, storage, and colorimetric sensing of sweat Koh, A.; Kang, D.; Xue, Y. Science Translational Medicine, Vol. 8, Issue 366 https://doi.org/10.1126/scitranslmed.aaf2593	journal	November 2016
Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System Kim, Jayoung; Jeerapan, Itthipon; Imani, Somayeh ACS Sensors, Vol. 1, Issue 8 https://doi.org/10.1021/acssensors.6b00356	journal	July 2016
Effects of moderate exercise on the pharmacokinetics of caffeine Collomp, K.; Anselme, F.; Audran, M. European Journal of Clinical Pharmacology, Vol. 40, Issue 3 https://doi.org/10.1007/BF00315209	journal	March 1991
Voltammetric sensor for caffeine based on a glassy carbon electrode modified with Nafion and graphene oxide Zhao, Fangyuan; Wang, Fei; Zhao, Weining Microchimica Acta, Vol. 174, Issue 3-4 https://doi.org/10.1007/s00604-011-0635-y	journal	June 2011
3D Printed “Earable” Smart Devices for Real-Time Detection of Core Body Temperature Ota, Hiroki; Chao, Minghan; Gao, Yuji ACS Sensors, Vol. 2, Issue 7 https://doi.org/10.1021/acssensors.7b00247	journal	July 2017
Proposal of sampling process for collecting human sweat and determination of caffeine concentration in it by using GC/MS Tsuda, Takao; Noda,, Saeko; Kitagawa, Shinya Biomedical Chromatography, Vol. 14, Issue 8 https://doi.org/10.1002/1099-0801(200012)14:8<505::AID-BMC17>3.0.CO;2-7	journal	January 2000
Carbon nanotube coating improves neuronal recordings Keefer, Edward W.; Botterman, Barry R.; Romero, Mario I. Nature Nanotechnology, Vol. 3, Issue 7 https://doi.org/10.1038/nnano.2008.174	journal	June 2008
Epidermal tattoo potentiometric sodium sensors with wireless signal transduction for continuous non-invasive sweat monitoring Bandodkar, Amay J.; Molinnus, Denise; Mirza, Omar Biosensors and Bioelectronics, Vol. 54 https://doi.org/10.1016/j.bios.2013.11.039	journal	April 2014
Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform Emaminejad, Sam; Gao, Wei; Wu, Eric Proceedings of the National Academy of Sciences, Vol. 114, Issue 18 https://doi.org/10.1073/pnas.1701740114	journal	April 2017
Interaction of the anticancer drug epirubicin with DNA Erdem, Arzum; Ozsoz, Mehmet Analytica Chimica Acta, Vol. 437, Issue 1 https://doi.org/10.1016/S0003-2670(01)00942-4	journal	June 2001
Hydrochromic conjugated polymers for human sweat pore mapping Lee, Joosub; Pyo, Minkyeong; Lee, Sang-hwa Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms4736	journal	April 2014
Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids Gao, Wei; Nyein, Hnin Y. Y.; Shahpar, Ziba ACS Sensors, Vol. 1, Issue 7 https://doi.org/10.1021/acssensors.6b00287	journal	May 2016
A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca ²⁺ and pH Nyein, Hnin Yin Yin; Gao, Wei; Shahpar, Ziba ACS Nano, Vol. 10, Issue 7 https://doi.org/10.1021/acsnano.6b04005	journal	July 2016
Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients Pirmohamed, Munir; James, Sally; Meakin, Shaun BMJ, Vol. 329, Issue 7456 https://doi.org/10.1136/bmj.329.7456.15	journal	July 2004
Highly deformable liquid-state heterojunction sensors Ota, Hiroki; Chen, Kevin; Lin, Yongjing Nature Communications, Vol. 5, Issue 1 https://doi.org/10.1038/ncomms6032	journal	September 2014
Electrochemical Tattoo Biosensors for Real-Time Noninvasive Lactate Monitoring in Human Perspiration Jia, Wenzhao; Bandodkar, Amay J.; Valdés-Ramírez, Gabriela Analytical Chemistry, Vol. 85, Issue 14, p. 6553-6560 https://doi.org/10.1021/ac401573r	journal	July 2013

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