Photocaged functional nucleic acids for spatiotemporal imaging in biology

Wu, Yuting; Yang, Zhenglin; Lu, Yi

doi:10.1016/j.cbpa.2020.05.003

Title: Photocaged functional nucleic acids for spatiotemporal imaging in biology

Journal Article · Wed Jul 08 00:00:00 EDT 2020 · Current Opinion in Chemical Biology

DOI:https://doi.org/10.1016/j.cbpa.2020.05.003· OSTI ID:1638459

Wu, Yuting ^[1]; Yang, Zhenglin ^[1]; Lu, Yi ^[1]

Univ. of Illinois at Urbana-Champaign, IL (United States)

Imaging of species in living organisms with high spatiotemporal resolution is essential for understanding biological processes. While functional nucleic acids (FNAs), such as catalytic nucleic acids and aptamers, have emerged as effective sensors for a wide range of molecules, photocaged control of these FNAs has played a key role in translating them into bioimaging agents with high spatiotemporal control. In this paper, we summarize methods and results of photocaged FNAs based on photolabile modifications, photoisomerization, and photothermal activation. Future directions, including strategies to improve the performance of these photocaged FNAs, are also described.

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Research Organization:: Center for Advanced Bioenergy and Bioproducts Innovation (CABBI), Urbana, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0018420

OSTI ID:: 1638459

Journal Information:: Current Opinion in Chemical Biology, Vol. 57, Issue C; ISSN 1367-5931

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Photocaged functional nucleic acids for spatiotemporal imaging in biology

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