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Title: Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites

Patent ·
OSTI ID:1632514

The present invention relates to genetically modified bacteria and methods of optimizing genetically modified bacteria for the production of a metabolite.

Research Organization:
Harvard Univ., Cambridge, MA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
FG02-02ER63445
Assignee:
President and Fellows of Harvard College (Cambridge, MA)
Patent Number(s):
10,550,384
Application Number:
14/775,025
OSTI ID:
1632514
Resource Relation:
Patent File Date: 02/26/2014
Country of Publication:
United States
Language:
English

References (19)

Bias in assessments of marine microbial biodiversity in fosmid libraries as evaluated by pyrosequencing journal April 2009
Selection of biocatalysts for chemical synthesis journal January 2006
Bacterial Mutants for Enhanced Succinate Production patent-application July 2011
Self-Replicating Vector Lacking an Antibiotic-Resistance Gene patent-application August 2011
Reversible, Parallel and Multitask Cloning Method and Kit patent-application May 2013
Method For Identifying A Biosynthetic Pathway Gene Product patent-application June 2007
Method for Producing High Amount of Glycolic Acid by Fermentation patent-application December 2012
Plasmid addiction systems: perspectives and applications in biotechnology journal April 2010
Tracking, tuning, and terminating microbial physiology using synthetic riboregulators journal August 2010
Linear DNA Molecule Delivery Using Pegylated Quantum Dots for Stable Trasformation in Plants patent-application January 2012
Bio-Field Programmable Gate Array and Bio-Programmable Logic Array: Reconfigurable Chassis Construction patent-application October 2011
Growth differentiation factor promoter and uses therefor patent April 2003
Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection journal May 2012
Engineered Microorganisms Capable of Producing Target Compounds Under Anaerobic Conditions patent-application July 2012
Method of Identifying Compounds Useful to Treat Neuronal Degenerative Diseases patent-application September 2009
Sensors For The Detection Of Intracellular Metabolites patent-application November 2013
Evolution-guided optimization of biosynthetic pathways journal December 2014
Regulated Transcription of Targeted Genes and Other Biological Events patent-application January 2011
mazEF: a chromosomal toxin-antitoxin module that triggers programmed cell death in bacteria journal September 2005

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