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Title: Genetic Influence on the Development of Renal Hypertension in Parabiotic rats: Evidence for a Humoral Factor

Journal Article · · Journal of Experimental Medicine
 [1];  [1];  [1];  [1];  [1]
  1. Brookhaven National Laboratory (BNL), Upton, NY (United States)
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The effects of several renal manipulations including uninephrectomy, unilateral renal artery constriction, and a combination of these two (Goldblatt procedure) were studied in two strains of rats with opposite constitutional predispositions to experimental hypertension. The protective value of intact renal tissue to protect against hypertension was shown to be genetically determined. The Goldblatt procedure carried out on only one member of a parabiotic pair induced hypertension in this operated rat but significant hypertension developed in the intact partner only when the operated animal belonged to the strain predisposed to hypertension. It was speculated that there were qualitative differences in the pressor signals of the two strains of rats. In the strain genetically predisposed to hypertension there are at least two pressor principles: (a) one which is common to both strains, not transmittable via the parabiosis junction and presumably related to the renin-angiotensin system; and (b) a second which is specific for the hypertension-prone strain and can be transmitted through the parabiosis junction. This transmittable agent is probably identical with the factor that produces salt hypertension and is associated with the salt-excreting mechanism.

Research Organization:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; Atomic Energy Commission
Grant/Contract Number:
SC0012704
OSTI ID:
1629171
Journal Information:
Journal of Experimental Medicine, Vol. 129, Issue 3; ISSN 0022-1007
Publisher:
Rockefeller University PressCopyright Statement
Country of Publication:
United States
Language:
English

Cited By (8)

Dahl salt-susceptible and salt-resistant rats. A review. journal November 1982
Genetic influence of the kidneys on blood pressure. Evidence from chronic renal homografts in rats with opposite predispositions to hypertension journal April 1977
Genetic Influence on the Renin-Angiotensin System: LOW RENIN ACTIVITIES IN HYPERTENSION-PRONE RATS journal June 1973
In vivo assessment of behavioral recovery and circulatory exchange in the peritoneal parabiosis model journal July 2016
Genetic Influence of the Kidneys on Blood Pressure: Evidence from Chronic Renal Homografts in Rats with Opposite Predispositions to Hypertension journal January 1974
Genetic Influence on the Renin-Angiotensin System journal March 1970
Endogenous cardiotonic steroids and salt-sensitive hypertension journal December 2010
A Novel Category of Anti-Hypertensive Drugs for Treating Salt-Sensitive Hypertension on the Basis of a New Development Concept journal January 2010

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59 BASIC BIOLOGICAL SCIENCES