An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)

Fox, Mary; Brewer, L.; Martin, Lawrence

doi:10.3390/ijerph14040389

Title: An Overview of Literature Topics Related to Current Concepts, Methods, Tools, and Applications for Cumulative Risk Assessment (2007–2016)

Journal Article · Fri Apr 07 00:00:00 EDT 2017 · International Journal of Environmental Research and Public Health

DOI:https://doi.org/10.3390/ijerph14040389· OSTI ID:1628340

Fox, Mary ^[1]; Brewer, L. ^[2];

^[3]

Johns Hopkins Univ., Baltimore, MD (United States). Department of Health Policy and Management, Bloomberg School of Public Health
Oak Ridge Inst. for Science and Education (ORISE), Washington, DC (United States). Office of the Science Advisor, U.S. Environmental Protection Agency
US Environmental Protection Agency (EPA), Washington, DC (United States). Office of the Science Advisor

Cumulative risk assessments (CRAs) address combined risks from exposures to multiple chemical and nonchemical stressors and may focus on vulnerable communities or populations. Significant contributions have been made to the development of concepts, methods, and applications for CRA over the past decade. Work in both human health and ecological cumulative risk has advanced in two different contexts. The first context is the effects of chemical mixtures that share common modes of action, or that cause common adverse outcomes. In this context two primary models are used for predicting mixture effects, dose addition or response addition. The second context is evaluating the combined effects of chemical and nonchemical (e.g., radiation, biological, nutritional, economic, psychological, habitat alteration, land-use change, global climate change, and natural disasters) stressors. CRA can be adapted to address risk in many contexts, and this adaptability is reflected in the range in disciplinary perspectives in the published literature. This article presents the results of a literature search and discusses a range of selected work with the intention to give a broad overview of relevant topics and provide a starting point for researchers interested in CRA applications.

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; USEPA

Grant/Contract Number:: SC0014664

OSTI ID:: 1628340

Journal Information:: International Journal of Environmental Research and Public Health, Vol. 14, Issue 4; ISSN 1660-4601

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Cited By (1)

Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents Zare Jeddi, Maryam; Eshaghi Gorji, Mohamad; Rietjens, Ivonne International Journal of Environmental Research and Public Health, Vol. 15, Issue 11 https://doi.org/10.3390/ijerph15112336	journal	October 2018

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