Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss

Martin, Tristan; Moussay, Sébastien; Bulla, Ingo; Bulla, Jan; Toupet, Michel; Etard, Olivier; Denise, Pierre; Davenne, Damien; Coquerel, Antoine; Quarck, Gaëlle; Challet, Etienne

doi:10.1371/journal.pone.0155067

Title: Exploration of Circadian Rhythms in Patients with Bilateral Vestibular Loss

Journal Article · Fri Jun 24 00:00:00 EDT 2016 · PLoS ONE

DOI:https://doi.org/10.1371/journal.pone.0155067· OSTI ID:1627788

Martin, Tristan ^[1]; Moussay, Sébastien ^[1]; Bulla, Ingo ^[2]; Bulla, Jan ^[3]; Toupet, Michel ^[4]; Etard, Olivier ^[5]; Denise, Pierre ^[6]; Davenne, Damien ^[1]; Coquerel, Antoine ^[7]; Quarck, Gaëlle ^[1]; Challet, Etienne

UNICAEN, COMETE, Caen (France); INSERM, Caen, (France); Normandie Universite, Caen (France)
Los Alamos National Lab. (LANL), Los Alamos, NM (United States). Theoretical Biology and Biophysics; Universität Greifswald (Germany). 8 Institut für Mathematik und Informatik
Bergen Univ. (Norway). Dept. of Mathematics
Centre d’explorations fonctionnelles oto-neurologiques, Paris (France)
Normandie Universite, Caen (France); CHU de Caen, Service des Explorations Fonctionnelles, Caen (France)
UNICAEN, COMETE, Caen (France); INSERM, Caen, (France); Normandie Universite, Caen (France); CHU de Caen, Service des Explorations Fonctionnelles, Caen (France)
UNICAEN, COMETE, Caen (France); INSERM, Caen, (France); Normandie Universite, Caen (France); CHU de Caen, Laboratoire de pharmacologie-toxicologie, Caen (France)

Background New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothalamic regulation of circadian rhythms on Earth, which raises the question of whether daily rhythms might be altered due to vestibular pathology in humans. The aim of this study was to evaluate human circadian rhythmicity in people presenting a total bilateral vestibular loss (BVL) in comparison with control participants. Methodology and Principal Findings Nine patients presenting a total idiopathic BVL and 8 healthy participants were compared. Their rest-activity cycle was recorded by actigraphy at home over 2 weeks. The daily rhythm of temperature was continuously recorded using a telemetric device and salivary cortisol was recorded every 3 hours from 6:00AM to 9:00PM over 24 hours. BVL patients displayed a similar rest activity cycle during the day to control participants but had higher nocturnal actigraphy, mainly during weekdays. Sleep efficiency was reduced in patients compared to control participants. Patients had a marked temperature rhythm but with a significant phase advance (73 min) and a higher variability of the acrophase (from 2:24 PM to 9:25 PM) with no correlation to rest-activity cycle, contrary to healthy participants. Salivary cortisol levels were higher in patients compared to healthy people at any time of day. Conclusion We observed a marked circadian rhythmicity of temperature in patients with BVL, probably due to the influence of the light dark cycle. However, the lack of synchronization between the temperature and rest-activity cycle supports the hypothesis that the vestibular inputs are salient input to the circadian clock that enhance the stabilization and precision of both external and internal entrainment.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1627788

Journal Information:: PLoS ONE, Vol. 11, Issue 6; ISSN 1932-6203

Publisher:: Public Library of ScienceCopyright Statement

Country of Publication:: United States

Language:: English

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