Cellular Assays for Ferredoxins: A Strategy for Understanding Electron Flow through Protein Carriers That Link Metabolic Pathways

Atkinson, Joshua T.; Campbell, Ian; Bennett, George N.; Silberg, Jonathan J.

doi:10.1021/acs.biochem.6b00831

Title: Cellular Assays for Ferredoxins: A Strategy for Understanding Electron Flow through Protein Carriers That Link Metabolic Pathways

Journal Article · Mon Nov 21 00:00:00 EST 2016 · Biochemistry

DOI:https://doi.org/10.1021/acs.biochem.6b00831· OSTI ID:1534417

Atkinson, Joshua T. ^[1]; Campbell, Ian ^[1]; Bennett, George N. ^[1];

^[1]

Rice Univ., Houston, TX (United States)

The ferredoxin (Fd) protein family is a structurally diverse group of iron–sulfur proteins that function as electron carriers, linking biochemical pathways important for energy transduction, nutrient assimilation, and primary metabolism. While considerable biochemical information about individual Fd protein electron carriers and their reactions has been acquired, we cannot yet anticipate the proportion of electrons shuttled between different Fd-partner proteins within cells using biochemical parameters that govern electron flow, such as holo-Fd concentration, midpoint potential (driving force), molecular interactions (affinity and kinetics), conformational changes (allostery), and off-pathway electron leakage (chemical oxidation). In this paper, we describe functional and structural gaps in our Fd knowledge within the context of a sequence similarity network and phylogenetic tree, and we propose a strategy for improving our understanding of Fd sequence–function relationships. We suggest comparing the functions of divergent Fds within cells whose growth, or other measurable output, requires electron transfer between defined electron donor and acceptor proteins. By comparing Fd-mediated electron transfer with biochemical parameters that govern electron flow, we posit that models that anticipate energy flow across Fd interactomes can be built. This approach is expected to transform our ability to anticipate Fd control over electron flow in cellular settings, an obstacle to the construction of synthetic electron transfer pathways and rational optimization of existing energy-conserving pathways.

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Research Organization:: Rice Univ., Houston, TX (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Science Foundation (NSF)

Grant/Contract Number:: SC0014462; R3E821

OSTI ID:: 1534417

Journal Information:: Biochemistry, Vol. 55, Issue 51; ISSN 0006-2960

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 34 works

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Figures / Tables (7)

Table 1(p. 28)

Table 1 (Continued)(p. 28)

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Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
59 BASIC BIOLOGICAL SCIENCES
Biochemistry & Molecular Biology
Redox reactions
Charge transfer
Peptides and proteins
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Cluster chemistry