Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Chung, Seok-Hwan; Hoffmann, Axel F.; Bader, Samuel D.

Title: Magneto-optic biosensor using bio-functionalized magnetized nanoparticles

Patent · Tue Dec 29 00:00:00 EST 2009

OSTI ID:1531619

Chung, Seok-Hwan; Hoffmann, Axel F.; Bader, Samuel D.

A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357; W-31-109-ENG-38

Assignee:: UChicago Argonne, LLC (Chicago, IL)

Patent Number(s):: 7,639,359

Application Number:: 11/875,475

OSTI ID:: 1531619

Resource Relation:: Patent File Date: 2007-10-19

Country of Publication:: United States

Language:: English

References (6)

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