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Title: Modular, micro-scale, optical array and biodetection system

Patent ·
OSTI ID:1531573

A modular, micro-scale, optical array and biodetection device for quantifying fluorescence intensities of a plurality of substantially separated, and dimensionally uniform elements of a bioarray that are located at known positions on a plain support includes a light guide that directs bioarray illumination light from a respective light source to opposing sides of the plain support. An optical module collecting light individually from the bioarray elements includes an optical member, a filter, and a sensor, such as a CCD chip. The optical member collects and transfers emitted light from the bioarray elements via the filter to the sensor. The filter transfers light from the elements having a predefined wavelength spectrum and blocks light outside the predefined wavelength spectrum. The sensor receives transferred light from the elements and produces a signal corresponding to respective elements of the bioarray.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
W-31-109-ENG-38
Assignee:
UChicago Argonne, LLC (Chicago, IL)
Patent Number(s):
7,463,353
Application Number:
11/444,241
OSTI ID:
1531573
Resource Relation:
Patent File Date: 2006-05-31
Country of Publication:
United States
Language:
English

References (11)

Reactor and process for production thereof patent March 2007
Device for producing microscopic arrays of molecules, a method for producing microscopic arrays of molecules patent February 2004
Optical analysis systems patent February 2006
Biochip detection system patent August 2001
Microfluidic Chip Capable of Synthesizing Radioactively Labeled Molecules on a Scale Suitable for Human Imaging with Positron Emission Tomography patent-application September 2007
Portable biochip scanner device patent June 2002
Portable wide-field optical system with microlenses and fiber-optic image transfer element patent April 2001
Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable patent October 2002
Method of dispensing microdoses of aqueous solutions of substances onto a carrier and a device for carrying out said method patent October 1999
Biochip scanner device patent December 2001
Biochip reader with enhanced illumination and bioarray positioning apparatus patent September 2003

Cited By (10)

Biosensors for biological or chemical analysis and systems and methods for same patent June 2018
Methods and systems for multiplex quantitative nucleic acid amplification patent November 2016
Integrated semiconductor bioarray patent October 2018
Methods and systems for multiplex quantitative nucleic acid amplification patent January 2019
Multiplexed analysis of nucleic acid hybridization thermodynamics using integrated arrays patent July 2017
Biosensors for biological or chemical analysis and systems and methods for same patent December 2014
Molecular reader patent May 2013
Multiplex Q-PCR arrays patent October 2016
Simultaneous, single-detector fluorescence detection of multiple analytes with frequency-specific lock-in detection patent May 2014
Integrated semiconductor bioarray patent January 2014

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