Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors
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March 2005 |
GABAA receptors: Subtypes provide diversity of function and pharmacology
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January 2009 |
Extrasynaptic GABAA Receptors: Their Function in the CNS and Implications for Disease
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January 2012 |
General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal
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May 2008 |
General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA A receptor β3 subunit
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February 2003 |
Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
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September 1997 |
Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels
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January 2011 |
Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol
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August 2016 |
Multiple Propofol-binding Sites in a γ-Aminobutyric Acid Type A Receptor (GABA A R) Identified Using a Photoreactive Propofol Analog
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August 2014 |
Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites
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November 2006 |
Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites
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October 2017 |
Structural basis for GABAA receptor potentiation by neurosteroids
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October 2017 |
Crystal structure of a human GABAA receptor
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June 2014 |
Structure of a human synaptic GABAA receptor
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June 2018 |
Modulation of GABAA receptor activity by alphaxalone
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March 1987 |
Tryptophan and Cysteine Mutations in M1 Helices of α1β3γ2L γ-Aminobutyric Acid Type A Receptors Indicate Distinct Intersubunit Sites for Four Intravenous Anesthetics and One Orphan Site
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January 2016 |
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
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March 2008 |
Ligand Activation of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC
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June 2011 |
The interaction of anaesthetic steroids with recombinant glycine and GABA A receptors †
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May 2004 |
Modulation of GABA A receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA A receptor isoforms
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September 1998 |
Common Anesthetic-binding Site for Inhibition of Pentameric Ligand-gated Ion Channels
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January 2016 |
Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC
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journal
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January 2017 |
X-ray structure of the human α4β2 nicotinic receptor
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journal
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October 2016 |
Principles of activation and permeation in an anion-selective Cys-loop receptor
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journal
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May 2011 |
X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors
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August 2014 |
Crystal structure of human glycine receptor-α3 bound to antagonist strychnine
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journal
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September 2015 |
X-ray structure of the mouse serotonin 5-HT3 receptor
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August 2014 |
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
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November 2008 |
Cryo-EM structure of 5-HT3A receptor in its resting conformation
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February 2018 |
Glycine receptor mechanism elucidated by electron cryo-microscopy
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journal
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September 2015 |
Coupling of agonist binding to channel gating in the GABAA receptor
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journal
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January 2003 |
An Asymmetric Contribution to γ-Aminobutyric Type A Receptor Function of a Conserved Lysine within TM2–3 of α1, β2, and γ2 Subunits
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journal
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April 2006 |
Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation
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journal
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December 2013 |
Identification of channel-lining residues in the M2 membrane-spanning segment of the GABA(A) receptor alpha1 subunit
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journal
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February 1996 |
Crystal Structures of Human GlyRα3 Bound to Ivermectin
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journal
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June 2017 |
The nicotinic acetylcholine receptor and its prokaryotic homologues: Structure, conformational transitions & allosteric modulation
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journal
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September 2015 |
A neurosteroid potentiation site can be moved among GABA A receptor subunits : Neurosteroid potentiation site and GABA
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October 2012 |
Conserved site for neurosteroid modulation of GABAA receptors
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journal
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January 2009 |
Allosteric and hyperekplexic mutant phenotypes investigated on an α 1 glycine receptor transmembrane structure
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journal
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February 2015 |
NMR structures of the human α7 nAChR transmembrane domain and associated anesthetic binding sites
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journal
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May 2014 |
Open-Channel Structures of the Human Glycine Receptor α1 Full-Length Transmembrane Domain
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journal
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October 2013 |
NMR structures of the transmembrane domains of the α4β2 nAChR
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journal
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May 2012 |
De novo GABRA1 mutations in Ohtahara and West syndromes
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journal
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February 2016 |
An outline of desensitization in pentameric ligand-gated ion channel receptors
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August 2012 |
Site-Directed Spin Labeling Reveals Pentameric Ligand-Gated Ion Channel Gating Motions
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journal
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November 2013 |
Conformational Changes Underlying Desensitization of the Pentameric Ligand-Gated Ion Channel ELIC
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journal
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June 2015 |
Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution
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journal
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March 2005 |
Mapping General Anesthetic Binding Site(s) in Human α1β3 γ-Aminobutyric Acid Type A Receptors with [ 3 H]TDBzl-Etomidate, a Photoreactive Etomidate Analogue
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journal
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January 2012 |
Mutational Analysis of the Putative High-Affinity Propofol Binding Site in Human β 3 Homomeric GABA A Receptors
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journal
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July 2015 |
Tryptophan Mutations at Azi-Etomidate Photo-Incorporation Sites on α 1 or β 2 Subunits Enhance GABA A Receptor Gating and Reduce Etomidate Modulation
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journal
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September 2008 |
The desensitization gate of inhibitory Cys-loop receptors
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journal
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April 2015 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |
Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues
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journal
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November 2010 |
MOLPROBITY: structure validation and all-atom contact analysis for nucleic acids and their complexes
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July 2004 |
VMD: Visual molecular dynamics
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February 1996 |
Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
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journal
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November 2012 |
Ensemble-Based Virtual Screening for Cannabinoid-Like Potentiators of the Human Glycine Receptor α1 for the Treatment of Pain
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journal
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March 2015 |
Large Influence of Cholesterol on Solute Partitioning into Lipid Membranes
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journal
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March 2012 |
g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbation
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journal
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March 2010 |
GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers
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September 2015 |
Rapid parameterization of small molecules using the force field toolkit
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journal
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September 2013 |
Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
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journal
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June 1993 |
Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine
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journal
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January 2012 |
Direct Pore Binding as a Mechanism for Isoflurane Inhibition of the Pentameric Ligand-gated Ion Channel ELIC
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journal
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September 2015 |
Improving the specificity of organophosphorus hydrolase to acephate by mutagenesis at its binding site: a computational study
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journal
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May 2021 |
Structural Basis of Alcohol Inhibition of the Pentameric Ligand-Gated Ion Channel ELIC
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journal
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February 2017 |
PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome
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journal
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December 2019 |
Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation
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journal
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February 2021 |
Rational identification and characterisation of peptide ligands for targeting polysialic acid
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journal
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May 2020 |
X-ray structure of a prokaryotic pentameric ligand-gated ion channel
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text
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January 2008 |
Inhibition of the Prokaryotic Pentameric Ligand-Gated Ion Channel ELIC by Divalent Cations
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text
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January 2012 |
Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
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text
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January 2009 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
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text
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January 2010 |
Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC
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text
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January 2011 |
CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields
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journal
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January 2009 |
The Sacred Disease: The Puzzling Genetics of Epileptic Disorders
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journal
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October 2013 |
A Functional Comparison of the Antagonists Bicuculline and Picrotoxin at Recombinant GABA A Receptors
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journal
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January 1996 |
Molecular basis for assembly of the shieldin complex and its implications for NHEJ
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journal
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April 2020 |
Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62
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journal
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January 2021 |
Desensitization Mechanism in Prokaryotic Ligand-gated Ion Channel
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journal
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April 2012 |
Conformational Transitions Underlying Pore Opening and Desensitization in Membrane-embedded Gloeobacter violaceus Ligand-gated Ion Channel (GLIC)
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journal
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September 2012 |
ELIC-α7 Nicotinic Acetylcholine Receptor (α7nAChR) Chimeras Reveal a Prominent Role of the Extracellular-Transmembrane Domain Interface in Allosteric Modulation
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journal
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April 2014 |
Anesthetic–Receptor Relationship Status: It’s Complicated
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journal
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December 2016 |
Alphaxalone Binds in Inner Transmembrane β+–α− Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors
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journal
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January 2018 |
Phaser crystallographic software
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journal
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July 2007 |
XDS
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journal
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January 2010 |
Features and development of Coot
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journal
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March 2010 |
How good are my data and what is the resolution?
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journal
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June 2013 |
Identification of a GABAA Receptor Anesthetic Binding Site at Subunit Interfaces by Photolabeling with an Etomidate Analog
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journal
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November 2006 |
Mutational analysis of molecular requirements for the actions of general anaesthetics at the γ-aminobutyric acidA receptor subtype, α1β2γ2
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text
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January 2003 |