Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals

Shi, Shuobo; Zhao, Huimin

doi:10.3389/fmicb.2017.02185

Title: Metabolic Engineering of Oleaginous Yeasts for Production of Fuels and Chemicals

Journal Article · Wed Nov 08 00:00:00 EST 2017 · Frontiers in Microbiology

DOI:https://doi.org/10.3389/fmicb.2017.02185· OSTI ID:1510464

Shi, Shuobo ^[1]; Zhao, Huimin ^[2]

Beijing Univ. of Chemical Technology (China); Science and Engineering Inst. (Singapore)
Beijing Univ. of Chemical Technology (China); Science and Engineering Inst. (Singapore); Univ. of Illinois, Urbana-Champaign, IL (United States)

Oleaginous yeasts have been increasingly explored for production of chemicals and fuels via metabolic engineering. Particularly, there is a growing interest in using oleaginous yeasts for the synthesis of lipid-related products due to their high lipogenesis capability, robustness, and ability to utilize a variety of substrates. Most of the metabolic engineering studies in oleaginous yeasts focused on Yarrowia that already has plenty of genetic engineering tools. However, recent advances in systems biology and synthetic biology have provided new strategies and tools to engineer those oleaginous yeasts that have naturally high lipid accumulation but lack genetic tools, such as Rhodosporidium, Trichosporon, and Lipomyces. This review highlights recent accomplishments in metabolic engineering of oleaginous yeasts and recent advances in the development of genetic engineering tools in oleaginous yeasts within the last 3 years.

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Research Organization:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0018260

OSTI ID:: 1510464

Journal Information:: Frontiers in Microbiology, Vol. 8; ISSN 1664-302X

Publisher:: Frontiers Research FoundationCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 58 works

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