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Title: Monte Carlo Treatment Planning for Molecular Targeted Radiotherapy within the MINERVA System

Abstract

The aim of this project is to extend accurate and patient-specific treatment planning to new treatment modalities, such as molecular targeted radiation therapy, incorporating previously crafted and proven Monte Carlo and deterministic computation methods. A flexible software environment is being created that allows planning radiation treatment for these new modalities and combining different forms of radiation treatment with consideration of biological effects. The system uses common input interfaces, medical image sets for definition of patient geometry, and dose reporting protocols. Previously, the Idaho National Engineering and Environmental Laboratory (INEEL), Montana State University (MSU), and Lawrence Livermore National Laboratory (LLNL) had accrued experience in the development and application of Monte Carlo-based, three-dimensional, computational dosimetry and treatment planning tools for radiotherapy in several specialized areas. In particular, INEEL and MSU have developed computational dosimetry systems for neutron radiotherapy and neutron capture therapy, while LLNL has developed the PEREGRINE computational system for external beam photon-electron therapy. Building on that experience, the INEEL and MSU are developing the MINERVA (Modality Inclusive Environment for Radiotherapeutic Variable Analysis) software system as a general framework for computational dosimetry and treatment planning for a variety of emerging forms of radiotherapy. In collaboration with this development, LLNL has extendedmore » its PEREGRINE code to accommodate internal sources for molecular targeted radiotherapy (MTR), and has interfaced it with the plug-in architecture of MINERVA. Results from the extended PEREGRINE code have been compared to published data from other codes, and found to be in general agreement (EGS4 - 2%, MCNP - 10%)(Descalle et al. 2003). The code is currently being benchmarked against experimental data. The interpatient variability of the drug pharmacokinetics in MTR can only be properly accounted for by image-based, patient-specific treatment planning as has been common in external beam radiation therapy for many years. MINERVA offers 3D Monte Carlo based MTR treatment planning as its first integrated operational capability. The new MINERVA system will ultimately incorporate capabilities for a comprehensive list of radiation therapies. In progress are modules for external beam photon-electron therapy and Boron Neutron Capture Therapy (BNCT). Brachytherapy and Protontherapy are planned. Through the open Application Programming Interface (API) other groups can add their own modules and share them with the community.« less

Authors:
; ; ; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
15014816
Report Number(s):
UCRL-PROC-206764
Journal ID: ISSN 0031-9155; TRN: US200807%%775
DOE Contract Number:  
W-7405-ENG-48
Resource Type:
Conference
Resource Relation:
Journal Volume: 50; Journal Issue: 5; Conference: Presented at: Current Topics in Monte Carlo Treatment Planning Advanced Workshop, Montreal, Canada, May 03 - May 05, 2004
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; BIOLOGICAL EFFECTS; DOSIMETRY; INEEL; LAWRENCE LIVERMORE NATIONAL LABORATORY; NEUTRON CAPTURE THERAPY; PLANNING; RADIOTHERAPY; THERAPY

Citation Formats

Lehmann, J, Siantar, C H, Wessol, D E, Wemple, C A, Nigg, D, Cogliati, J, Daly, T, Descalle, M, Flickinger, T, Pletcher, D, and DeNardo, G. Monte Carlo Treatment Planning for Molecular Targeted Radiotherapy within the MINERVA System. United States: N. p., 2004. Web. doi:10.1088/0031-9155/50/5/017.
Lehmann, J, Siantar, C H, Wessol, D E, Wemple, C A, Nigg, D, Cogliati, J, Daly, T, Descalle, M, Flickinger, T, Pletcher, D, & DeNardo, G. Monte Carlo Treatment Planning for Molecular Targeted Radiotherapy within the MINERVA System. United States. https://doi.org/10.1088/0031-9155/50/5/017
Lehmann, J, Siantar, C H, Wessol, D E, Wemple, C A, Nigg, D, Cogliati, J, Daly, T, Descalle, M, Flickinger, T, Pletcher, D, and DeNardo, G. 2004. "Monte Carlo Treatment Planning for Molecular Targeted Radiotherapy within the MINERVA System". United States. https://doi.org/10.1088/0031-9155/50/5/017. https://www.osti.gov/servlets/purl/15014816.
@article{osti_15014816,
title = {Monte Carlo Treatment Planning for Molecular Targeted Radiotherapy within the MINERVA System},
author = {Lehmann, J and Siantar, C H and Wessol, D E and Wemple, C A and Nigg, D and Cogliati, J and Daly, T and Descalle, M and Flickinger, T and Pletcher, D and DeNardo, G},
abstractNote = {The aim of this project is to extend accurate and patient-specific treatment planning to new treatment modalities, such as molecular targeted radiation therapy, incorporating previously crafted and proven Monte Carlo and deterministic computation methods. A flexible software environment is being created that allows planning radiation treatment for these new modalities and combining different forms of radiation treatment with consideration of biological effects. The system uses common input interfaces, medical image sets for definition of patient geometry, and dose reporting protocols. Previously, the Idaho National Engineering and Environmental Laboratory (INEEL), Montana State University (MSU), and Lawrence Livermore National Laboratory (LLNL) had accrued experience in the development and application of Monte Carlo-based, three-dimensional, computational dosimetry and treatment planning tools for radiotherapy in several specialized areas. In particular, INEEL and MSU have developed computational dosimetry systems for neutron radiotherapy and neutron capture therapy, while LLNL has developed the PEREGRINE computational system for external beam photon-electron therapy. Building on that experience, the INEEL and MSU are developing the MINERVA (Modality Inclusive Environment for Radiotherapeutic Variable Analysis) software system as a general framework for computational dosimetry and treatment planning for a variety of emerging forms of radiotherapy. In collaboration with this development, LLNL has extended its PEREGRINE code to accommodate internal sources for molecular targeted radiotherapy (MTR), and has interfaced it with the plug-in architecture of MINERVA. Results from the extended PEREGRINE code have been compared to published data from other codes, and found to be in general agreement (EGS4 - 2%, MCNP - 10%)(Descalle et al. 2003). The code is currently being benchmarked against experimental data. The interpatient variability of the drug pharmacokinetics in MTR can only be properly accounted for by image-based, patient-specific treatment planning as has been common in external beam radiation therapy for many years. MINERVA offers 3D Monte Carlo based MTR treatment planning as its first integrated operational capability. The new MINERVA system will ultimately incorporate capabilities for a comprehensive list of radiation therapies. In progress are modules for external beam photon-electron therapy and Boron Neutron Capture Therapy (BNCT). Brachytherapy and Protontherapy are planned. Through the open Application Programming Interface (API) other groups can add their own modules and share them with the community.},
doi = {10.1088/0031-9155/50/5/017},
url = {https://www.osti.gov/biblio/15014816}, journal = {},
issn = {0031-9155},
number = 5,
volume = 50,
place = {United States},
year = {Wed Sep 22 00:00:00 EDT 2004},
month = {Wed Sep 22 00:00:00 EDT 2004}
}

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