A Mononuclear Nonheme Iron(IV)–Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Lu, Xiaoyan; Li, Xiao-Xi; Seo, Mi Sook; Lee, Yong-Min; Clémancey, Martin; Maldivi, Pascale; Latour, Jean-Marc; Sarangi, Ritimukta; Fukuzumi, Shunichi; Nam, Wonwoo

doi:10.1021/jacs.8b11045

Title: A Mononuclear Nonheme Iron(IV)–Amido Complex Relevant for the Compound II Chemistry of Cytochrome P450

Journal Article · Sat Nov 24 00:00:00 EST 2018 · Journal of the American Chemical Society

DOI:https://doi.org/10.1021/jacs.8b11045· OSTI ID:1493335

Lu, Xiaoyan ^[1]; Li, Xiao-Xi ^[1]; Seo, Mi Sook ^[1];

^[1]; Clémancey, Martin ^[2]; Maldivi, Pascale ^[2]; Latour, Jean-Marc ^[2];

^[3];

^[1];

^[1]

Ewha Womans Univ., Seoul (Korea). Dept. of Chemistry and Nano Science
Univ. Grenoble Alpes, Genoble (France)
SLAC National Accelerator Lab., Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)

A mononuclear nonheme iron(IV)–amido complex bearing a tetraamido macrocyclic ligand, [(TAML)Fe^IV(NHTs)]^- (1), was synthesized via a hydrogen atom (H atom) abstraction reaction of an iron(V)–imido complex, [(TAML)FeV(NTs)]- (2), and fully characterized using various spectroscopies. We then investigated (1) the pK_a of 1, (2) the reaction of 1 with a carbon-centered radical, and (3) the H atom abstraction reaction of 1. To the best of our knowledge, the present study reports for the first time the synthesis and chemical properties/reactions of a high-valent iron(IV)–amido complex.

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Research Organization:: SLAC National Accelerator Lab., Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Institutes of Health (NIH)

Grant/Contract Number:: AC02-76SF00515; P41GM103393; A0040807648

OSTI ID:: 1493335

Journal Information:: Journal of the American Chemical Society, Vol. 141, Issue 1; ISSN 0002-7863

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 17 works

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